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NCT04729023
Pars Plana Vitrectomy Combined With Phacoemulsification Cataract Surgery in Phakic Diabetes Retinopathy Patients
NA trial testing Pars plana vitrectomy combined with cataract surgery. in Diabetic Retinopathy in 129 participants. Completed in 5 September 2022.
2 September 2022
Quick facts
| Lead sponsor | Zhongshan Ophthalmic Center, Sun Yat-sen University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 129 |
| Start date | 1 February 2021 |
| Primary completion | 2 September 2022 |
| Estimated completion | 5 September 2022 |
| Sites | 1 location across China |
Drugs / interventions tested
- Pars plana vitrectomy combined with cataract surgery.
- Pars plana vitrectomy with subsequent cataract surgery.
Conditions studied
- Diabetic Retinopathy — all drugs for Diabetic Retinopathy →
- Diabetic Cataract — all drugs for Diabetic Cataract →
Sponsor
Zhongshan Ophthalmic Center, Sun Yat-sen University
Who can join
45 and older, any sex, with Diabetic Retinopathy or Diabetic Cataract. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Pars plana vitrectomy (PPV) is one of the most widely used surgical therapies to proliferative diabetic retinopathy in the world. However, as a predictable consequence of PPV surgery, postoperative cataract is observed in 79%-95% of phakic diabetes retinopathy patients after PPV in 6-24 months and a subsequent cataract surgery is usually required. While, the subsequent cataract surgeries not only bring additional economy and workload burden, but also increase the surgical risks. Since the two-step surgical approach has its defects, the combination of PPV and phacoemulsification is an ideal surgical option. This study is a multi-center prospective study, aimed to evaluate the effect of PPV combined with phacoemulsification cataract surgery in phakic diabetes retinopathy patients, and make a comparation between the combined surgery and the two-step surgery in patients without severe lens opacities.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract: a randomized clinical trial.
Feng WB, Zheng L, Li YQ, Li YH, et al · · 2024 · cited 3× · PMID 38721515 · DOI 10.18240/ijo.2024.03.15 -
Effectiveness and Safety of Vitrectomy Combined with Cataract Surgery Concurrently Versus Vitrectomy with Subsequent Cataract Surgery for Proliferative Diabetic Retinopathy Patients with Mild-moderate Cataract: A Multicenter Randomized Controlled Study
feng w, Zheng L, Zhang G, wang x, et al · · 2023 · DOI 10.21203/rs.3.rs-2653898/v1
Verify or expand the search:
- PubMed search for NCT04729023
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Zhongshan Ophthalmic Center, Sun Yat-sen University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04729023 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zhongshan Ophthalmic Center, Sun Yat-sen University
- Last refreshed: 9 September 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04729023.
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