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NCT04725851: HOPE
High Concentration Oxygen for Pneumocephalus After Evacuation of Chronic Subdural Haematoma
NA trial testing High concentration Oxygen therapy in Chronic Subdural Hematoma in 36 participants. Status unknown.
31 December 2023
Quick facts
| Lead sponsor | Chinese University of Hong Kong |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 36 |
| Start date | 26 July 2022 |
| Primary completion | 31 December 2023 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- High concentration Oxygen therapy
- Control: Room Air or Low concentration Oxygen
Conditions studied
- Chronic Subdural Hematoma — all drugs for Chronic Subdural Hematoma →
- Recurrence — all drugs for Recurrence →
- Oxycephaly — all drugs for Oxycephaly →
Sponsor
Chinese University of Hong Kong
Who can join
18 and older, any sex, with Chronic Subdural Hematoma or Recurrence. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Normobaric oxygen therapy was shown to be effective in reducing post craniotomy pneumocephalus. Theoretical assessment of normobaric oxygen therapy in treating pneumocephalus has shown that a higher level of oxygen concentration will significantly decrease the time for absorption of pneumocephalus. The therapeutic efficacy is not fully established in patients with chronic subdural hematoma after burr hole drainage. Both radiological outcomes and clinical outcomes would be evaluated.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Updated systematic review of current randomised controlled trials in chronic subdural haematoma.
Fakhry R, Yesildal C, Bartek J, Duerinck J, et al · · 2025 · PMID 41196366 · DOI 10.1007/s00701-025-06683-5
Verify or expand the search:
- PubMed search for NCT04725851
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Chronic Subdural Hematoma
Currently open trials in the same condition.
- NCT07245264 — Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) · Phase 2, PHASE3 · recruiting
- NCT07144423 — Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma · NA · recruiting
- NCT07324551 — Microfabricated Microcatheter Advantages in Middle Meningeal Artery Embolization: an Early Experience at a Single Center · recruiting
- NCT07421453 — Implementation of an Enhanced Recovery Pathway for Burr-hole Drainage in Patients With a Chronic Subdural Hematoma · recruiting
- NCT06772740 — Middle Meningeal Artery Embolization for Patients With Chronic Subdural Hematoma · NA · recruiting
Other Chinese University of Hong Kong trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04725851 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
- Last refreshed: 28 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04725851.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing