NCT04724200 (OPERA) is a clinical trial of Echocardiogram in Heart Failure, sponsored by NHS Greater Glasgow and Clyde.

Who is sponsoring NCT04724200?

NCT04724200 is sponsored by NHS Greater Glasgow and Clyde.

What drugs are being tested in NCT04724200?

Interventions in NCT04724200: Echocardiogram.

What condition does NCT04724200 study?

NCT04724200 studies Heart Failure.

Is NCT04724200 still recruiting?

NCT04724200 is currently completed. Last updated 28 March 2024.

Last reviewed 2024-03-28 · How we verify

NCT04724200: OPERA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Optimising a Digital Diagnostic Pathway for Heart Failure in the Community

Completed Last updated 28 March 2024

What this trial tests

trial testing Echocardiogram in Heart Failure in 867 participants. Completed in 31 December 2023.

Timeline

5 January 2021

Primary endpoint
27 August 2021

31 December 2023

Quick facts

Lead sponsor	NHS Greater Glasgow and Clyde
Status	Completed
Study type	OBSERVATIONAL
Enrollment	867
Start date	5 January 2021
Primary completion	27 August 2021
Estimated completion	31 December 2023
Sites	1 location across United Kingdom

Drugs / interventions tested

Echocardiogram

Conditions studied

Heart Failure — all drugs for Heart Failure →

Sponsor

NHS Greater Glasgow and Clyde — full company profile →

Who can join

18 and older, any sex, with Heart Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a prospective, observational study. The primary aim is to assess the diagnostic accuracy of Artificial Intelligence (AI) analysis of Point of Care (POC) handheld transthoracic echocardiogram images (POC handheld echocardiogram) compared to the current gold-standard of transthoracic echocardiogram images acquired and analysed by a British Society of Echocardiography (BSE) accredited operator, using a standard echocardiogram machine (standard TTE), for the diagnosis of Heart Failure with reduced Ejection Fraction (HFrEF), in patients referred from the community for investigation of suspected new Heart Failure (HF).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Artificial intelligence fully automated analysis of handheld echocardiography in real-world patients with suspected heart failure.
Campbell RT, Petrie MC, Docherty KF, Brooksbank KJM, et al · · 2025 · cited 2× · PMID 40702880 · DOI 10.1002/ejhf.3783
A digital diagnostic pathway for heart failure: an economic evaluation.
Mcmeekin N, Davies A, Petrie MC, Campbell RT, et al · · 2026 · PMID 41495745 · DOI 10.1186/s12962-025-00695-9

Verify or expand the search:

Other trials of Echocardiogram

Trials testing the same drug.

NCT07438301 — Septic Shock Hemodynamic Respond to Volume Resuscitation Versus Vasopressor Administration · not yet recruiting
NCT07058064 — WATCH (Wearable Artificial inTelligence for Cardiac Function and Health Monitoring) · NA · recruiting
NCT06927973 — Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction · NA · completed
NCT07132788 — Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass · active not recruiting
NCT06622928 — Ventriculo-Arterial Coupling and Intra-Dialytic Changes in Hemodialysis Patients: Prognostic Insights · not yet recruiting

Other recruiting trials for Heart Failure

Currently open trials in the same condition.

NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
NCT07496372 — Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart · Phase 3 · recruiting
NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting

Other NHS Greater Glasgow and Clyde trials

Trials by the same sponsor.

NCT07403890 — Rewiring the Brain-Immune Axis for Chronic Pain Using Transcranial Magnetic Stimulation in Psoriatic Arthritis · NA · not yet recruiting
NCT07372508 — Glasgow Low-dose CT and AI-based Diagnostics to Case Find Lung Cancer and Other Cardio-respiratory Long-term Conditions · NA · not yet recruiting
NCT07391280 — Strategy for EArly Recognition of Cancer, COPD & Heart Failure in the Emergency Department · NA · not yet recruiting
NCT07048184 — Sarcoma Surgery Wound Complications Comparing Usual Versus Negative Pressure Dressing · Phase 2 · not yet recruiting
NCT06786936 — Evaluating the Role of IL-17 as an Orchestrator of Peripheral-central Cross Talk in Depressive Symptoms · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04724200 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by NHS Greater Glasgow and Clyde
Last refreshed: 28 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04724200.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing