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NCT04723979
NovoSeven® in Severe Postpartum Haemorrhage - Experiences From UK, DK, FR, NL
trial testing Eptacog alfa in Post Partum Hemorrhage in 3,322 participants. Completed in 31 January 2021.
1 January 2021
Quick facts
| Lead sponsor | Leiden University Medical Center |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 3,322 |
| Start date | 1 May 2020 |
| Primary completion | 1 January 2021 |
| Estimated completion | 31 January 2021 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Eptacog alfa (EPTACOG ALFA (ACTIVATED)) — full drug profile →
- Standard of care
Conditions studied
- Post Partum Hemorrhage — all drugs for Post Partum Hemorrhage →
Sponsor
Leiden University Medical Center
Who can join
18 and older, female only, with Post Partum Hemorrhage. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overall aim of this project is to include currently available information from women with severe postpartum haemorrhage (sPPH) who were treated with NovoSeven® and to examine whether NovoSeven® may have affected the course of the PPH in these women, specifically the control of bleeding. Data will be included from previous cohort studies from four countries: United Kingdom (UK), the Netherlands, Denmark, and France.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Efficacy and Safety Analyses of Recombinant Factor VIIa in Severe Post-Partum Hemorrhage.
Caram-Deelder C, McKinnon Edwards H, Zdanowicz JA, van den Akker T, et al · · 2024 · cited 3× · PMID 38731185 · DOI 10.3390/jcm13092656 -
Efficacy and Safety Analysis of Recombinant Factor VIIa in Severe Post-partum Hemorrhage
Caram-Deelder C, McKinnon Edwards H, Zdanowicz JA, Van den Akker T, et al · · 2024 · DOI 10.20944/preprints202403.0153.v1
Verify or expand the search:
- PubMed search for NCT04723979
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Eptacog alfa
Trials testing the same drug.
- NCT03196284 — A Trial Evaluating the Efficacy and Safety of Prophylactic Administration of Concizumab in Haemophilia A and B Patients · Phase 2 · completed
Other recruiting trials for Post Partum Hemorrhage
Currently open trials in the same condition.
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- NCT06577922 — Evaluation of Maternal & Newborn Health Simulation Lab Centers of Excellence in Nepal · NA · recruiting
- NCT05370820 — Prevention of Postpartum Hemorrhage With Tranexamic Acid · Phase 2 · recruiting
Other Leiden University Medical Center trials
Trials by the same sponsor.
- NCT07312565 — Occurrence of Abdominal Aortic Aneurysms in Patients With Aneurysmal Subarachnoid Hemorrhage · not yet recruiting
- NCT07090343 — Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement · Phase 3 · not yet recruiting
- NCT07498738 — Making Diabetes Care Fit for Young Adults Living With Type 1 Diabetes: Observations, Reflections and Expert Opinions · NA · not yet recruiting
- NCT06545292 — Microsampling for Therapeutic Drug Monitoring of Oral Oncolytics in Oncology Patients · NA · recruiting
- NCT07021495 — SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY) · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04723979 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Leiden University Medical Center
- Last refreshed: 11 May 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04723979.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing