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NCT04720573
Reversal of Neuromuscular Blockade and Perioperative Arrhythmias
NA trial testing Neostigmine in Neuromuscular Blockade in 80 participants. Completed in 1 November 2019.
1 October 2019
Quick facts
| Lead sponsor | Başakşehir Çam & Sakura City Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 80 |
| Start date | 1 June 2019 |
| Primary completion | 1 October 2019 |
| Estimated completion | 1 November 2019 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Neostigmine (NEOSTIGMINE) — full drug profile →
- Sugammadex — full drug profile →
Conditions studied
- Neuromuscular Blockade — all drugs for Neuromuscular Blockade →
Sponsor
Başakşehir Çam & Sakura City Hospital
Who can join
Adults 18 to 75, any sex, with Neuromuscular Blockade. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients scheduled for elective abdominopelvic laparoscopic surgery under general anesthesia were included. Rocuronium was used for the neuromuscular blockade (NMB) and the level of NMB was monitored with train-of-four (TOF) measurements. The participants from whom informed consent had been received were allocated to two groups according to the agent used for reversal of NMB, sugammadex, or neostigmine. The ECG recordings of the subjects were followed with a rhythm Holter device throughout the procedure until the postoperative 12th hour. Additionally, preoperative and immediate postoperative 12-lead ECGs were evaluated for corrected QT calculations and QT dispersion. Proarrhythmogenicity was assessed with QT related measurements. The documented arrhythmic events on the Holter monitoring were designated as clinical end-points.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04720573
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Neostigmine
Trials testing the same drug.
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- NCT07203287 — Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease · Phase 4 · recruiting
- NCT06729047 — Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Pati · Phase 1, PHASE2 · not yet recruiting
- NCT06982092 — Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine. · Phase 1 · completed
Other recruiting trials for Neuromuscular Blockade
Currently open trials in the same condition.
- NCT07203287 — Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease · Phase 4 · recruiting
- NCT06945341 — International Focus Group Discussion on Neuromuscular Monitoring. · recruiting
- NCT06948409 — NMBA Reversal and Postoperative Urinary Retention · active not recruiting
- NCT07003061 — Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery · recruiting
- NCT06679569 — Deep Neuromuscular Blockade on Postoperative Pain · NA · recruiting
Other Başakşehir Çam & Sakura City Hospital trials
Trials by the same sponsor.
- NCT07403682 — M-TAPA vs ESPB for Postoperative Analgesia After Laparoscopic Cholecystectomy · NA · not yet recruiting
- NCT07199049 — Neuro-Mimic Indicators of Anesthesia Depth During General Anesthesia · not yet recruiting
- NCT07194707 — Effect of Operating Room Noise on BIS and Hemodynamics Under General Anesthesia · not yet recruiting
- NCT07327125 — Effect of Skin Closure Techniques on Body Image in Women Undergoing Gynecologic Surgery · NA · recruiting
- NCT07453641 — White Noise and Crying Duration After Invasive Procedures in Infants · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04720573 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Başakşehir Çam & Sakura City Hospital
- Last refreshed: 22 January 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04720573.
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