Last reviewed · How we verify
NCT04720404
Mindful Prevention of Psychopathology in Healthcare Workers During the COVID-19 Crisis (COVID-19 MindPreP)
NA trial testing Mindfulness-Based Stress Reduction in Mindfulness in 201 participants. Completed in 9 June 2022.
2 June 2022
Quick facts
| Lead sponsor | Radboud University Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 201 |
| Start date | 23 June 2020 |
| Primary completion | 2 June 2022 |
| Estimated completion | 9 June 2022 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Mindfulness-Based Stress Reduction
- Self-help mindfulness/compassion exercises
- Support as usual
Conditions studied
- Mindfulness — all drugs for Mindfulness →
- Randomized Controlled Trial — all drugs for Randomized Controlled Trial →
- Psychopathology — all drugs for Psychopathology →
- Health Personnel — all drugs for Health Personnel →
Sponsor
Radboud University Medical Center
Who can join
18 and older, any sex, with Mindfulness or Randomized Controlled Trial. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The current study will be a randomized controlled trial (RCT) investigating an adapted online Mindfulness-Based Stress Reduction (MBSR) program versus daily online self-help mindfulness exercises, in preventing incident/prevalent psychopathology in healthcare workers allocated to work with COVID-19 patients. Outcome measures include depression, anxiety, somatoform symptoms, post-traumatic stress, insomnia, substance abuse, post-traumatic growth and positive mental health. The study also aims to explore possible working mechanisms such as perseverative thinking, mindfulness skills and self-compassion. The study will have a follow-up duration of 7 months from baseline.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Effectiveness of online mindfulness-based interventions in improving mental health during the COVID-19 pandemic: A systematic review and meta-analysis of randomized controlled trials.
Witarto BS, Visuddho V, Witarto AP, Bestari D, et al · · 2022 · cited 43× · PMID 36129900 · DOI 10.1371/journal.pone.0274177 -
Mindfulness-Based Interventions for Mental Health Outcomes in Frontline Healthcare Workers During the COVID-19 Pandemic: A Randomized Controlled Trial.
Arts-de Jong M, Geurts DEM, Spinhoven P, Ruhé HG, et al · · 2025 · cited 2× · PMID 40388083 · DOI 10.1007/s11606-025-09529-z
Verify or expand the search:
- PubMed search for NCT04720404
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Mindfulness-Based Stress Reduction
Trials testing the same drug.
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- NCT06789952 — Mindfulness-Based Stress Reduction Versus Lifestyle Intervention for Long-Haul Covid-19 Parosmia · NA · terminated
- NCT06228950 — Mindfulness-Based Intervention for Emotional and Behavioural Problems of Students With Visual Impairment · NA · unknown
- NCT05516355 — Psychological and Neurobiological Impact of a Retreat Based on Mindfulness and Compassion for Stress Reduction. · NA · completed
- NCT04977245 — Mindfulness-Based Stress Reduction in Dementia Caregivers · NA · completed
Other recruiting trials for Mindfulness
Currently open trials in the same condition.
- NCT07351799 — Mindfulness and Meditation Based Lactation Education on Maternal Breastmilk in the Neonatal ICU · NA · recruiting
- NCT07171697 — Mindful-Med: the Evaluation of the Mindfulness-based Stress-coping and Burnout Prevention Programme for Medical Interns. · NA · active not recruiting
- NCT06642181 — Combined Guanfacine and Mindfulness Meditation as an Adjunct to Buprenorphine Maintenance in Opioid Use Disorder · Phase 1 · recruiting
- NCT07195838 — Mindful-Breath for People With COPD · NA · recruiting
- NCT07285954 — Mindfulness Walking Intervention to Enhance Resilience (iWalk) · NA · recruiting
Other Radboud University Medical Center trials
Trials by the same sponsor.
- NCT07485569 — Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial · Phase 1 · not yet recruiting
- NCT07514325 — MR-guided Adaptive Stereotactic Radiotherapy for Endometrial Cancer · NA · not yet recruiting
- NCT07530263 — Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA) · Phase 1 · not yet recruiting
- NCT07532577 — Intranasal Insulin to Prevent Intensive Care Unit Delirium · Phase 2, PHASE3 · not yet recruiting
- NCT07504172 — Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04720404 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
- Last refreshed: 12 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04720404.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing