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NCT04719026: PEDICAD
PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY
trial testing Full-mouth periodontal examination using computerised Florida probe in Myocardial Infarction, Acute in 320 participants. Status unknown.
31 December 2022
Quick facts
| Lead sponsor | University of Aberdeen |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 320 |
| Start date | 16 February 2018 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Full-mouth periodontal examination using computerised Florida probe
Conditions studied
- Myocardial Infarction, Acute — all drugs for Myocardial Infarction, Acute →
- Periodontitis — all drugs for Periodontitis →
Sponsor
University of Aberdeen
Who can join
Adults 20 to 90, any sex, with Myocardial Infarction, Acute or Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Heart attack remains a major cause of death in adult population worldwide and especially within Scotland. A large portion of the general population has an increased risk of suffering from a heart attack because of their genetic make-up, disease profile and lifestyle choices. Literature suggests that apart from these known risk factors, long-standing inflammation (reaction of tissues to infection or injury) elsewhere in the body may be responsible for heart attacks. It has been suggested that gum disease may be one such condition. If left untreated, gum disease may expose the entire body to a long-term inflammatory burden where inflammatory molecules can disseminate from the gums into the bloodstream and affect various body structures. This study explores the influence of gum disease on the risk of heart attack by comparing the gum health of participants who recently had a heart attack to the gum health of participants with no history of heart problems after accounting for other risk factors. Findings will provide critical information for the design of our forthcoming study to establish the effect of treatment of gum disease on the risk of heart attack, and its cost-effectiveness. Ultimately this research will tackle another risk factor for heart attacks and thus inform enhancement of public health prevention strategies.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Myocardial infarction risk is increased by periodontal pathobionts: a cross-sectional study.
Joshi C, Mezincescu A, Gunasekara M, Rudd A, et al · · 2022 · cited 4× · PMID 36329042 · DOI 10.1038/s41598-022-19154-z
Verify or expand the search:
- PubMed search for NCT04719026
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04719026 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Aberdeen
- Last refreshed: 22 January 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04719026.
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