NCT04715113 (HEXABM) is a NA clinical trial of Normobaric hypoxia (FiO2 15%) in Hypertension, Pulmonary, sponsored by University of Zurich.

Who is sponsoring NCT04715113?

NCT04715113 is sponsored by University of Zurich.

What drugs are being tested in NCT04715113?

Interventions in NCT04715113: Normobaric hypoxia (FiO2 15%), Placebo-ambient air (FiO2 21%), Normobaric hypoxia (FiO2 15%) under Sildenafil, Placebo-ambient air (FiO2 21%) under Sildenafil.

What condition does NCT04715113 study?

NCT04715113 studies Hypertension, Pulmonary.

Is NCT04715113 still recruiting?

NCT04715113 is currently completed. Last updated 6 June 2023.

Last reviewed 2023-06-06 · How we verify

NCT04715113: HEXABM

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Blood Markers Predict Effect of Normobaric Hypoxia at Rest and During Exercise in Patients With Pulmonary Hypertension

Completed NA Last updated 6 June 2023

What this trial tests

NA trial testing Normobaric hypoxia (FiO2 15%) in Hypertension, Pulmonary in 24 participants. Completed in 31 May 2023.

Timeline

1 February 2021

Primary endpoint
31 May 2023

31 May 2023

Quick facts

Lead sponsor	University of Zurich
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	treatment
Enrollment	24
Start date	1 February 2021
Primary completion	31 May 2023
Estimated completion	31 May 2023
Sites	1 location across Switzerland

Drugs / interventions tested

Normobaric hypoxia (FiO2 15%)
Placebo-ambient air (FiO2 21%)
Normobaric hypoxia (FiO2 15%) under Sildenafil
Placebo-ambient air (FiO2 21%) under Sildenafil

Conditions studied

Hypertension, Pulmonary — all drugs for Hypertension, Pulmonary →

Sponsor

University of Zurich

Who can join

18 and older, any sex, with Hypertension, Pulmonary. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To study the effect of acute normobaric hypoxia during exercise in patients with pulmonary hypertension on blood markers (serum markers of iron and red blood cell homeostasis and micro-RNAs known to be associated with PH).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms.
Quatredeniers M, Mendes-Ferreira P, Santos-Ribeiro D, Nakhleh MK, et al · · 2021 · cited 31× · PMID 33672218 · DOI 10.3390/cells10020477

Verify or expand the search:

Other trials of Normobaric hypoxia (FiO2 15%)

Trials testing the same drug.

NCT04697862 — Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension Receiving Sildenafil · NA · completed
NCT04704440 — Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension With/Without Sildenafil · NA · completed
NCT04697875 — Hemodynamic Effects of Normobaric Hypoxia During Exercise in Patients With Pulmonary Hypertension · NA · completed

Other recruiting trials for Hypertension, Pulmonary

Currently open trials in the same condition.

NCT07087613 — Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG · recruiting
NCT06814145 — Extension Study of Sotatercept in People With Pulmonary Hypertension (MK-7962-023) · Phase 2 · recruiting
NCT05867914 — Early Feasibility Study Evaluating the 3P-100 Device in Subjects With PH-ILD · NA · active not recruiting
NCT05719415 — Functional Pulmonary Capillary Surface Area in BPA for CTEPH · NA · recruiting
NCT05179876 — A Study Providing Treatment Access in Participants With Pulmonary Hypertension Completing a Parent Study and Having no O · Phase 3 · recruiting

Other University of Zurich trials

Trials by the same sponsor.

NCT07485699 — Soy Processing and Food Allergy · NA · not yet recruiting
NCT07516912 — Evaluation of Free STI Testing Pilot Projects in Lucerne and Zurich, Switzerland · not yet recruiting
NCT07473115 — Individualized Analgesia in the Intensive Care Unit With a New Pain Assessment Bundle and Protocolized Analgesia Adjustm · not yet recruiting
NCT07524023 — Emotional-distress-based Integrated Care Programme in Patients With Stable COPD · NA · recruiting
NCT06481982 — Value of Advanced MRI Techniques in the Assessment of Endometriosis · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04715113 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Zurich
Last refreshed: 6 June 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04715113.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing