Who is sponsoring NCT04713332?

NCT04713332 is sponsored by University of Jordan.

What drugs are being tested in NCT04713332?

Interventions in NCT04713332: Vitamin E, Hydrogen rich water, placebo.

What condition does NCT04713332 study?

NCT04713332 studies Radiation-induced Injuries in Patients With Rectal Cancer.

Is NCT04713332 still recruiting?

NCT04713332 is currently status unknown. Last updated 17 February 2021.

Last reviewed 2021-02-17 · How we verify

NCT04713332

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effectiveness of Vitamin E and Hydrogen-Rich Water on Radiation Therapy-Induced Adverse In Patients With Rectal Cancer

Status unknown Phase 3 Last updated 17 February 2021

What this trial tests

Phase 3 trial testing Vitamin E in Radiation-induced Injuries in Patients With Rectal Cancer in 60 participants. Status unknown.

Timeline

6 July 2019

Primary endpoint
8 March 2021

8 May 2021

Quick facts

Lead sponsor	University of Jordan
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	supportive care
Enrollment	60
Start date	6 July 2019
Primary completion	8 March 2021
Estimated completion	8 May 2021
Sites	1 location across Palestinian Territories

Drugs / interventions tested

Vitamin E (VITAMIN E) — full drug profile →
Hydrogen rich water
placebo

Conditions studied

Radiation-induced Injuries in Patients With Rectal Cancer — all drugs for Radiation-induced Injuries in Patients With Rectal Cancer →

Sponsor

University of Jordan

Who can join

18 and older, any sex, with Radiation-induced Injuries in Patients With Rectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Controlled studies investigating the effects of vitamin E or H2 water or comparing their effectiveness on radiation therapy-induced injuries in RC patients are generally lacking. The present study hypothesis the following: (1) Pre - radiation therapy administration of vitamin E to patients with rectal carcinoma will provide radioprotection for exposed healthy tissues. (2) Consumption of H2 water by patients with rectal carcinoma undergoing RT will reduce the side effects of this modality. (3) Rectal cancer patients receiving H2 water will show better biological improvement than those receiving only vitamin E, i.e., H2 water is more effective antioxidant than vitamin E. (4) The proposed radiation countermeasures will not compromise the anti-tumor effects.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential.
Xiao YL, Gong Y, Qi YJ, Shao ZM, et al · · 2024 · cited 120× · PMID 38462638 · DOI 10.1038/s41392-024-01771-x
Ionizing radiation: molecular mechanisms, biological effects, and therapeutic targets.
Wei W, Ren Y, Lan J, Yi J, et al · · 2026 · PMID 41507636 · DOI 10.1186/s43556-025-00358-4

Verify or expand the search:

Other trials of Vitamin E

Trials testing the same drug.

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NCT06211478 — Role of Vitamin E in Gaucher Disease Patients · Phase 3 · completed
NCT04801849 — Vitamin E Dosing Study · Phase 2 · completed

Other University of Jordan trials

Trials by the same sponsor.

NCT07370545 — Impact of Presentation Sequence on Patient Tooth Shade Selection · NA · completed
NCT07279285 — Sweet-Tasting Solution Versus Placebo to Reduce Pain During Local Anesthetic Injection in Children · NA · not yet recruiting
NCT07310485 — Examining the Impact of Phytoestrogens Supplementation on the Gene Expression, and Premenstrual Syndrome in Primenopausa · NA · enrolling by invitation
NCT06977009 — Influence of Occlusal Reduction on Endodontic Postoperative Pain · NA · recruiting
NCT07212413 — Effect of Snow-plow Technique on the Postoperative Pain Following Direct Composite Restoration · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04713332 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Jordan
Last refreshed: 17 February 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04713332.

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