NCT04713124: R2C-M

A Telephone-delievered Intervention to Reduce Methamphetamine Use

Completed NA Last updated 7 August 2025

What this trial tests

NA trial testing R2C-M in Methamphetamine Use Disorder in 204 participants. Completed in 25 January 2024.

Timeline

4 February 2021

Primary endpoint
1 May 2023

25 January 2024

Quick facts

Lead sponsor	Turning Point
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	204
Start date	4 February 2021
Primary completion	1 May 2023
Estimated completion	25 January 2024
Sites	1 location across Australia

Drugs / interventions tested

• R2C-M
• Self-help booklet

Conditions studied

• Methamphetamine Use Disorder — all drugs for Methamphetamine Use Disorder →

Sponsor

Turning Point — full company profile →

Who can join

18 and older, any sex, with Methamphetamine Use Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Australia has one of the highest rates of methamphetamine use in the world; however, uptake of face-to-face psychological treatment remains extremely low due to numerous individual (e.g. stigma, shame) and structural (e.g. service availability, geography) barriers to accessing care. Addressing these barriers through the provision of alternative treatment delivery models is imperative, particularly as effective and earlier intervention is likely to reduce the need for more costly and intensive treatment resulting from escalating methamphetamine use.

In this project, the investigators will conduct the first double-blind, parallel-group, randomised controlled trial (RCT) examining the effectiveness of the structured telephone-delivered intervention, Ready2Change (R2C), among participants with methamphetamine use problems (R2C-M). Cost effectiveness of R2C-M will also be investigated. Factors influencing program implementation will be evaluated to inform the scalability of this intervention for practice nationally, and for replication internationally.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. A structured, telephone-delivered intervention to reduce methamphetamine use: study protocol for a parallel-group randomised controlled trial.
   Lubman DI, Manning V, Arunogiri S, Hall K, et al · · 2023 · cited 1× · PMID 36991490 · DOI 10.1186/s13063-023-07172-9
2. A structured, telephone-delivered intervention to reduce methamphetamine use: Study protocol for a parallel group randomised controlled trial
   Lubman D, Manning V, Arunogiri S, Hall K, et al · · 2023 · DOI 10.21203/rs.3.rs-2399893/v1