NCT04711928: HPAC

The Association Between Sedentary Behaviour and Cardiometabolic Health in Trained Athletes

Completed Last updated 15 March 2022

What this trial tests

trial testing Physical activity and sedentary behaviour in Cardiometabolic Health in 60 participants. Completed in 1 October 2021.

Timeline

10 January 2021

Primary endpoint
1 August 2021

1 October 2021

Quick facts

Lead sponsor	Hasselt University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	60
Start date	10 January 2021
Primary completion	1 August 2021
Estimated completion	1 October 2021
Sites	1 location across Belgium

Drugs / interventions tested

• Physical activity and sedentary behaviour

Conditions studied

• Cardiometabolic Health — all drugs for Cardiometabolic Health →
• Sedentary Behavior — all drugs for Sedentary Behavior →
• Physical Activity — all drugs for Physical Activity →
• Athletes — all drugs for Athletes →

Sponsor

Hasselt University

Who can join

Adults 18 to 45, any sex, with Cardiometabolic Health or Sedentary Behavior. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Physical inactivity is one of the major contributing factors for the development of chronic diseases and highly correlated with increased all-cause mortality. In the last decade an exponential growth in research concerned with the study of sedentary behaviour and the potential for detrimental effects on health have been published. In this field increasing evidence suggests that prolonged periods of sedentary time, independent of the amount of physical activity, also increases the risk for the development of several chronic conditions and all-cause mortality. Here, sedentary behaviour is defined as "any waking behaviour, characterized by a low energy expenditure (≤1.5 METs), while being in a sitting or reclining posture". Interestingly, the advised moderate-to-vigorous bouts of exercise recommended by the various guidelines cannot compensate the negative impact on health risks arising from prolonged periods of sitting. In other words, it seems that people compensate their total amount of physical activity after exercise training by decreasing their physical activity levels throughout the rest of the day. Here, it appears that frequent, even low-intensity interruptions of periods of sitting are required for good cardiometabolic health. Therefore, not only physical activity but also prolonged sitting should be targeted to optimize cardiometabolic health. Nevertheless, a recent harmonized meta-syntheses indicated that the association between self-reported sitting with all-cause and cardiovascular disease mortality are only partially independent of physical activity, but were particularly evident in those who undertake insufficient physical activity (\<150min/week). However, it is unclear whether high amounts of objectively measured physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. In addition, it is still unclear whether high amounts of physical activity can preserve a healthy cardiometabolic risk profile, despite prolonged sitting. Therefore, in this study we want to investigate the association between sedentary behaviour, physical activity and cardiometabolic health in highly physically active adults.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The potential harms of sedentary behaviour on cardiometabolic health are mitigated in highly active adults: a compositional data analysis.
   Franssen WMA, Jermei J, Savelberg HHCM, Eijnde BO. · · 2023 · PMID 40217441 · DOI 10.1186/s44167-023-00015-7