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NCT04710693
Implementation of Optical Diagnosis of Diminutive Colorectal Polyps: DISCARD3 Study (Incorporating AI-DETECT)
NA trial testing CAD polyp-detection system in Colonic Polyp in 614 participants. Completed in 3 December 2021.
3 December 2021
Quick facts
| Lead sponsor | London North West Healthcare NHS Trust |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 614 |
| Start date | 14 February 2020 |
| Primary completion | 3 December 2021 |
| Estimated completion | 3 December 2021 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- CAD polyp-detection system
Conditions studied
- Colonic Polyp — all drugs for Colonic Polyp →
Sponsor
London North West Healthcare NHS Trust — full company profile →
Who can join
Adults 55 to 74, any sex, with Colonic Polyp. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a prospective feasibility study. The aim of this work is to assess the acceptability and feasibility of optical diagnosis-led care in bowel cancer screening patients undergoing colonoscopy. This study will determine whether bowel cancer screening colonoscopists are able to consistently record and diagnose diminutive adenomas suitable for a resect and discard strategy allowing assignment of surveillance intervals according to Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI) criteria. A practical quality assurance program around optical diagnosis will be introduced. The use of a CAD polyp-detection system will also be evaluated (AI-DETECT).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Implementation of optical diagnosis with a "resect and discard" strategy in clinical practice: DISCARD3 study.
Ahmad A, Moorghen M, Wilson A, Stasinos I, et al · · 2022 · cited 23× · PMID 35724693 · DOI 10.1016/j.gie.2022.06.019
Verify or expand the search:
- PubMed search for NCT04710693
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other recruiting trials for Colonic Polyp
Currently open trials in the same condition.
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- NCT07456111 — A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy · Phase 4 · recruiting
- NCT06483503 — Extra Wide Field of View Lens Study · active not recruiting
- NCT06077435 — Comparative Analysis of AI Software for Enhanced Polyp Detection and Diagnosis · NA · recruiting
Other London North West Healthcare NHS Trust trials
Trials by the same sponsor.
- NCT07271264 — A Randomised Paired Design Study of Texture and Colour Enhancement Imaging (TXI) Versus High-definition White Light Endo · NA · recruiting
- NCT07298655 — 3D Contrast Enhanced Microvascular Ultrasound of Carotid Atherosclerosis for the Detection of Carotid Plaque Neo-Revascu · NA · recruiting
- NCT07208214 — Texture and Colour Enhancement Imaging (TXI) Versus Dye Chromoendoscopy for Dysplasia Detection in IBD Surveillance. · NA · not yet recruiting
- NCT05583968 — Efficiency of AI Reporting (EAIR). · withdrawn
- NCT06447961 — PSYLIVED: the Psychological Impacts of Living With an Inherited Colorectal Cancer Predisposition Syndrome · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04710693 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by London North West Healthcare NHS Trust
- Last refreshed: 22 December 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04710693.
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