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NCT04706494
A Study to Investigate the Efficacy of AlphaWave® L-Theanine on Stress
Phase 1 trial testing AlphaWave® LTheanine in Stress in 16 participants. Completed in 25 September 2020.
25 September 2020
Quick facts
| Lead sponsor | Ethical Naturals, Inc. |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | other |
| Enrollment | 16 |
| Start date | 2 February 2020 |
| Primary completion | 25 September 2020 |
| Estimated completion | 25 September 2020 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- AlphaWave® LTheanine
- Placebo
Conditions studied
- Stress — all drugs for Stress →
Sponsor
Ethical Naturals, Inc.
Who can join
Adults 18 to 65, any sex, with Stress. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
AlphaWave® L-theanine will be compared against placebo to evaluate how the investigational study product effects on salivary cortisol, EEG readings, blood pressure, and heart rate in a moderately stressed and otherwise healthy adult population. It is hypothesized that participants taking the AlphaWave® L-theanine will have reduced stress levels as assessed by the parameters stated. Participants will be consuming the investigational study product or placebo in the clinic only.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave<sup>®</sup> L-Theanine on Stress in a Healthy Adult Population.
Evans M, McDonald AC, Xiong L, Crowley DC, et al · · 2021 · cited 12× · PMID 34562208 · DOI 10.1007/s40120-021-00284-x
Verify or expand the search:
- PubMed search for NCT04706494
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Ethical Naturals, Inc. trials
Trials by the same sponsor.
- NCT05808595 — The Safety and Efficacy of AlphaWave® L-Theanine on Adults Who Experience Moderate Stress on a Regular Basis · Phase 2 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04706494 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ethical Naturals, Inc.
- Last refreshed: 12 January 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04706494.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing