Who is sponsoring KETO-COX?

KETO-COX is sponsored by University of Aarhus.

What condition does KETO-COX study?

KETO-COX studies Heart Failure, Systolic, Ketonemia.

What drugs are being tested in KETO-COX?

Interventions: Placebo NaCl, Niacin, Na-3-OHB.

What is the status of KETO-COX?

KETO-COX is currently COMPLETED.

Last reviewed 2021-12-03 · How we verify

Effects of Ketones and Niacin in Heart Failure Patients (KETO-COX)

NCT04703361 PHASE2 COMPLETED

Ketones, 3-hydroxybutyrate (3-OHB), have shown to have beneficial hemodynamics effect in patients with hearth failure with reduced ejection fraction. The mechanisms behind these marked hemodynamic effects are currently unknown, but could involve prostaglandin-release. 3-OHB is the endogenous ligand for the G protein-coupled receptor hydroxy-carboxylic acid 2 (HCA2) receptor. This receptor has proven downstream effects on cAMP and systemic effects via release of prostaglandins. In this present study we will investigate the cardiovascular effects of HCA2-receptor stimulation in heart failure patients.

Details

Lead sponsor	University of Aarhus
Phase	PHASE2
Status	COMPLETED
Enrolment	12
Start date	Mon Feb 15 2021 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Fri Sep 03 2021 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Heart Failure, Systolic
Ketonemia

Interventions

Placebo NaCl
Niacin
Na-3-OHB

Countries

Denmark