Who is sponsoring NCT04700631?

NCT04700631 is sponsored by Centre Hospitalier Universitaire, Amiens.

What drugs are being tested in NCT04700631?

Interventions in NCT04700631: urinary extracellular vesicle concentration, blood sample.

What condition does NCT04700631 study?

NCT04700631 studies Chronic Renal Failure, Urinary Extracellular Vesicle.

Is NCT04700631 still recruiting?

NCT04700631 is currently completed. Last updated 19 September 2025.

Last reviewed 2025-09-19 · How we verify

NCT04700631: VE-IRC

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Extracellular Vesicles as Biomarkers for Chronic Renal Failure

Completed NA Last updated 19 September 2025

What this trial tests

NA trial testing urinary extracellular vesicle concentration in Chronic Renal Failure in 143 participants. Completed in 1 July 2023.

Timeline

1 January 2021

Primary endpoint
1 July 2023

1 July 2023

Quick facts

Lead sponsor	Centre Hospitalier Universitaire, Amiens
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	143
Start date	1 January 2021
Primary completion	1 July 2023
Estimated completion	1 July 2023
Sites	1 location across France

Drugs / interventions tested

urinary extracellular vesicle concentration
blood sample — full drug profile →

Conditions studied

Chronic Renal Failure — all drugs for Chronic Renal Failure →
Urinary Extracellular Vesicle — all drugs for Urinary Extracellular Vesicle →

Sponsor

Centre Hospitalier Universitaire, Amiens

Who can join

18 and older, any sex, with Chronic Renal Failure or Urinary Extracellular Vesicle. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

A Brief Overview of Global Trends in MSC-Based Cell Therapy.
Jovic D, Yu Y, Wang D, Wang K, et al · · 2022 · cited 186× · PMID 35344199 · DOI 10.1007/s12015-022-10369-1
Exosome-mediated renal protection: Halting the progression of fibrosis.
Liu C, Li Q, Ma JX, Lu B, et al · · 2024 · cited 10× · PMID 39263535 · DOI 10.1016/j.gendis.2023.101117
Quantification of Urine and Plasma Levels of Extracellular Vesicles in a Cohort of Kidney Transplant Recipients and Chronic Kidney Disease Patients.
Jacob V, de Berny Q, Brazier F, Presne C, et al · · 2025 · cited 1× · PMID 40332150 · DOI 10.3390/ijms26083635
Breaking barriers in peritoneal fibrosis: extracellular vesicles as promising diagnostic and therapeutic strategy.
Zhong L, Zhang B, Li Y, Su B, et al · · 2026 · PMID 42015747 · DOI 10.1080/07853890.2026.2659509
Mesenchymal stem cell-derived extracellular vesicles for disease therapy by regulating ferroptosis: focus on diabetes mellitus and diabetic complications.
Wu J, Zhou Z, Qian H. · · 2025 · PMID 41382238 · DOI 10.1186/s13287-025-04852-y

Verify or expand the search:

Other recruiting trials for Chronic Renal Failure

Currently open trials in the same condition.

NCT06227468 — A Clinical Study to Map the HLA Genomic Region in the Greek Population · recruiting
NCT06347029 — Evaluation of Endothelial Dysfunction Using the "Flow Mediated Dilation" Test in a Population of Chronic Renal Failure P · NA · recruiting
NCT05884866 — A Study to Investigate the Mechanistic Effects of Dapagliflozin Alone or in Combination With Balcinrenone, Compared to B · Phase 2 · recruiting
NCT05353946 — Coronary Rotational Atherectomy Elective vs. Bailout in Severely Calcified Lesions and Chronic Renal Failure · NA · recruiting

Other Centre Hospitalier Universitaire, Amiens trials

Trials by the same sponsor.

NCT07354568 — Prognosis of Patients With Mixed Cardiogenic-Vasoplegic Shock · recruiting
NCT07071662 — Induction of Labor in Breech Presentation · completed
NCT06909487 — Clinical Characterization of Very and Extremely Preterm Infants Who Received Excess Erythrocyte Transfusions With Respec · completed
NCT07037719 — Automatic Detection of Eligible Patients to RAUC Protocol (RAUCISABLE) · recruiting
NCT06996145 — Study of the Isometry of the Anterior Cruciate Ligament From the Center of the Native MRI Insertion Reported on Dynamic · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04700631 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire, Amiens
Last refreshed: 19 September 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04700631.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing