NCT04698551 is a clinical trial of Non invasive prenatal diagnosis in Myotonic Dystrophy 1, sponsored by University Hospital, Montpellier.

Who is sponsoring NCT04698551?

NCT04698551 is sponsored by University Hospital, Montpellier.

What drugs are being tested in NCT04698551?

Interventions in NCT04698551: Non invasive prenatal diagnosis.

What condition does NCT04698551 study?

NCT04698551 studies Myotonic Dystrophy 1, Huntington Disease, Fragile X Syndrome.

Is NCT04698551 still recruiting?

NCT04698551 is currently status unknown. Last updated 7 January 2021.

Last reviewed 2021-01-07 · How we verify

NCT04698551

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

NIPD on cffDNA for Triplet Repeat Diseases

Status unknown Last updated 7 January 2021

What this trial tests

trial testing Non invasive prenatal diagnosis in Myotonic Dystrophy 1 in 36 participants. Status unknown.

Timeline

1 September 2020

Primary endpoint
1 September 2023

1 December 2023

Quick facts

Lead sponsor	University Hospital, Montpellier
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	36
Start date	1 September 2020
Primary completion	1 September 2023
Estimated completion	1 December 2023
Sites	1 location across France

Drugs / interventions tested

Non invasive prenatal diagnosis

Conditions studied

Myotonic Dystrophy 1 — all drugs for Myotonic Dystrophy 1 →
Huntington Disease — all drugs for Huntington Disease →
Fragile X Syndrome — all drugs for Fragile X Syndrome →

Sponsor

University Hospital, Montpellier

Who can join

18 Months and older, any sex, with Myotonic Dystrophy 1 or Huntington Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purprose of this study is to develop and validate an analytical NIPD test for triplet repeat disesases by NGS analysis from maternal blood, searching for the familial mutation in families at risk of having one of the following triplet repeat diseases: Huntington's disease, Myotonic dystrophy, Fragile X syndrome.. A comparison of two 3rd generation long fragment DNA sequencing techniques will be performed. These methods are based of the phasing techniques of parental haplotypes without the proband.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Noninvasive prenatal diagnosis of genetic diseases induced by triplet repeat expansion by linked read haplotyping and Bayesian approach.
Liautard-Haag C, Durif G, VanGoethem C, Baux D, et al · · 2022 · cited 4× · PMID 35794169 · DOI 10.1038/s41598-022-15307-2

Verify or expand the search:

Other trials of Non invasive prenatal diagnosis

Trials testing the same drug.

NCT03743948 — NIPD of CFTC by WGA Coupled to Mini-exome Sequencing · NA · unknown
NCT03087526 — NIPD on CFTC for Triplet Repeat Diseases · NA · completed

Other recruiting trials for Myotonic Dystrophy 1

Currently open trials in the same condition.

NCT07385443 — The Spanish National Registry for Myotonic Dystrophy Type 1 · recruiting
NCT06378216 — Myotonic Dystrophy Type 1 Congenital and Juvenile Form: From Diagnosis to Rehabilitation [MDCJ-NeuBeRe] · recruiting
NCT03981575 — Estab Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1) · recruiting

Other University Hospital, Montpellier trials

Trials by the same sponsor.

NCT07524127 — Phenotyping of Type 2 Inflammation Profile by Rheology of Nasal Secretions and Tissue Quantification of Eosinophilic Pol · NA · not yet recruiting
NCT07255495 — Effects of Neuromuscular Scoliosis Surgery on Nutritional Metabolism · NA · not yet recruiting
NCT07534189 — Prospective Cohort Study Evaluating a Thermal Spa Programme in Symptomatic Knee Osteoarthritis · NA · not yet recruiting
NCT07515638 — Immun4Cure Cohort of Autoimmune Diseases · not yet recruiting
NCT07406516 — Identification of Kinematic Variables Specific of Patellar Tendinopathy in Athletes at Risk · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04698551 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Montpellier
Last refreshed: 7 January 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04698551.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing