NCT04694833: AutoRReVi

Telerehabilitation Through Serious Games in Virtual Reality in a Stroke Population (AutoRReVi)

Status unknown NA Last updated 15 June 2022

What this trial tests

NA trial testing Motor and cognitive virtual reality-based assessments in Stroke in 400 participants. Status unknown.

Timeline

23 October 2020

Primary endpoint
30 August 2022

15 October 2022

Quick facts

Lead sponsor	Université Catholique de Louvain
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	400
Start date	23 October 2020
Primary completion	30 August 2022
Estimated completion	15 October 2022
Sites	1 location across Belgium

Drugs / interventions tested

• Motor and cognitive virtual reality-based assessments
• Motor and cognitive virtual reality-based serious games

Conditions studied

• Stroke — all drugs for Stroke →
• Hemiparesis — all drugs for Hemiparesis →
• Cognitive Impairment — all drugs for Cognitive Impairment →
• Healthy Subjects — all drugs for Healthy Subjects →

Sponsor

Université Catholique de Louvain — full company profile →

Who can join

18 and older, any sex, with Stroke or Hemiparesis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

After a stroke, individuals present with motor and/or cognitive impairments. These impairments limit activity, restrict participation and affect quality of life. Therefore, rehabilitation programs are provided from the earliest days. However, an important proportion of patients do not achieve the recommended amount of rehabilitation therapy (even in institutional systems). In fact, patients do not always have access to healthcare systems. Moreover, hospital resources and healthcare systems are often limited (especially in poor countries) which has led to the development of new cost-effective rehabilitation methods such as self-rehabilitation and tele-rehabilitation.

This study aims :

1. to develop and validate relevant self-assessments tools in virtual reality
2. to propose auto-adaptative virtual reality-based therapies based on the link between motor and cognitive functions.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Concurrent validity of an immersive virtual reality version of the Box and Block Test to assess manual dexterity among patients with stroke.
   Everard G, Otmane-Tolba Y, Rosselli Z, Pellissier T, et al · · 2022 · cited 35× · PMID 35065678 · DOI 10.1186/s12984-022-00981-0
2. Performing a shortened version of the Action Research Arm Test in immersive virtual reality to assess post-stroke upper limb activity.
   Burton Q, Lejeune T, Dehem S, Lebrun N, et al · · 2022 · cited 18× · PMID 36463219 · DOI 10.1186/s12984-022-01114-3
3. Extended reality to assess post-stroke manual dexterity: contrasts between the classic box and block test, immersive virtual reality with controllers, with hand-tracking, and mixed-reality tests.
   Everard G, Burton Q, Van de Sype V, Bibentyo TN, et al · · 2024 · cited 16× · PMID 38491540 · DOI 10.1186/s12984-024-01332-x
4. A Self-Adaptive Serious Game to Improve Motor Learning Among Older Adults in Immersive Virtual Reality: Short-Term Longitudinal Pre-Post Study on Retention and Transfer.
   Everard G, Declerck L, Lejeune T, Edwards MG, et al · · 2025 · cited 3× · PMID 40053708 · DOI 10.2196/64004
5. The REAsmash serious game for the post-stroke diagnosis of distractor inhibition: contrast between immersive and non-immersive virtual reality test versions.
   Sorrentino G, Ajana K, Everard G, Vanhoof F, et al · · 2025 · cited 2× · PMID 40047653 · DOI 10.23736/s1973-9087.25.08680-0
6. REAsmash-ET: a methodological framework for combined cognitive and motor assessment through eye-tracking and kinematic metrics in immersive VR search-and-reach task.
   Sorrentino G, Edwards MG, Baldini N, Mustile M, et al · · 2025 · cited 1× · PMID 41408291 · DOI 10.1186/s12984-025-01844-0
7. Cognitive inhibition difficulties in individuals with hemiparesis: Evidence from an immersive virtual reality target-distractor salience contrast visual search serious game
   Ajana K, Everard G, Sorrentino G, Lejeune T, et al · · 2023 · cited 1× · DOI 10.21203/rs.3.rs-3111608/v1
8. An immersive virtual reality serious game set for the clinical assessment of spatial attention impairments: Effects of avatars on perspective?
   Ajana K, Everard G, Lejeune T, Edwards MG. · · 2025 · PMID 39973878 · DOI 10.1177/09287329241296380