NCT04694261 (SM-ART) is a NA clinical trial of SM-ART in Perinatal Depression, sponsored by Aga Khan University.

Who is sponsoring NCT04694261?

NCT04694261 is sponsored by Aga Khan University.

What drugs are being tested in NCT04694261?

Interventions in NCT04694261: SM-ART.

What condition does NCT04694261 study?

NCT04694261 studies Perinatal Depression, Resilience, Anxiety, Marital Conflict.

Is NCT04694261 still recruiting?

NCT04694261 is currently completed. Last updated 3 March 2022.

Last reviewed 2022-03-03 · How we verify

NCT04694261: SM-ART

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Development and Evaluation of SM-ART Intervention (SM-ART)

Completed NA Last updated 3 March 2022

What this trial tests

NA trial testing SM-ART in Perinatal Depression in 200 participants. Completed in 31 December 2021.

Timeline

1 July 2019

Primary endpoint
30 June 2021

31 December 2021

Quick facts

Lead sponsor	Aga Khan University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	200
Start date	1 July 2019
Primary completion	30 June 2021
Estimated completion	31 December 2021
Sites	1 location across Pakistan

Drugs / interventions tested

SM-ART

Conditions studied

Perinatal Depression — all drugs for Perinatal Depression →
Resilience — all drugs for Resilience →
Anxiety — all drugs for Anxiety →
Marital Conflict — all drugs for Marital Conflict →

Sponsor

Aga Khan University

Who can join

18 and older, female only, with Perinatal Depression or Resilience. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The approach of this intended research is to help pregnant women practice constructive coping and proactive skills that focus on positive adaptation for safe motherhood through our developed intervention. The objective of this two phases Randomized Control Trial is to develop contextually based "SM-ART" intervention \[Safe Motherhood ART: Accessible Resilience Training\] and evaluate the effectiveness of "SM-ART" intervention in a sample of pregnant women living in low socioeconomic urban areas of Karachi, Pakistan. It is hypothesized that the SM-ART intervention will enhance resilience and marital harmony and decrease symptoms of depression, anxiety in pregnant women.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Promoting mental wellbeing in pregnant women living in Pakistan with the Safe Motherhood-Accessible Resilience Training (SM-ART) intervention: a randomized controlled trial.
Bhamani SS, Van Parys AS, Arthur D, Letourneau N, et al · · 2024 · cited 1× · PMID 38951777 · DOI 10.1186/s12884-024-06629-2

Verify or expand the search:

Other recruiting trials for Perinatal Depression

Currently open trials in the same condition.

NCT06790641 — Pathways to Perinatal Mental Health Equity · NA · recruiting
NCT06968390 — Accelerated TMS for Perinatal Depression · NA · recruiting
NCT06594263 — Validation of the French Version of the Perinatal Assessment of Paternal Affectivity (PAPA) · recruiting
NCT06364488 — TrueBlue Clinical Study - Investigating the Use of a Mobile Phone App TrueBlue for Monitoring Depression and Anxiety · NA · recruiting
NCT06473935 — Maternal Well-being in the Perinatal Period · recruiting

Other Aga Khan University trials

Trials by the same sponsor.

NCT07475793 — Image Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis · NA · not yet recruiting
NCT07197684 — Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surg · NA · not yet recruiting
NCT07356063 — Self-Efficacy Enhancement Using a Multicomponent Support Group for Caregivers of Children With DMD/SMA · NA · not yet recruiting
NCT07451951 — Effectiveness of SQLNS vs MQLNS for Prevention of Undernutrition in Children 6-12 Months · NA · not yet recruiting
NCT07357350 — Effectiveness of Pain Management Interventions in Patients With Abdominal and Pelvic Cancer · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04694261 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Aga Khan University
Last refreshed: 3 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04694261.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing