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NCT04693611
Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme
NA trial testing Individual cognitive stimulation therapy (iCST) in Dementia in 36 participants. Completed in 31 August 2021.
30 April 2021
Quick facts
| Lead sponsor | CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 36 |
| Start date | 14 April 2021 |
| Primary completion | 30 April 2021 |
| Estimated completion | 31 August 2021 |
| Sites | 1 location across Portugal |
Drugs / interventions tested
- Individual cognitive stimulation therapy (iCST)
- Functional near-infrared spectroscopy (fNIRS)
Conditions studied
- Dementia — all drugs for Dementia →
- Neurocognitive Disorders — all drugs for Neurocognitive Disorders →
- Cognitive Impairment — all drugs for Cognitive Impairment →
- Cognitive Dysfunction — all drugs for Cognitive Dysfunction →
Sponsor
CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
Who can join
65 and older, any sex, with Dementia or Neurocognitive Disorders. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This research aims to evaluate the effect of cognitive stimulation (CS) on the functioning of the prefrontal cortex (PFC), seeking an analysis of both cerebral hemodynamics in neuroplasticity and aspects related to the initiation of neurodegenerative processes. The intervention presents an individual format and the participants are elderly without or with neurocognitive disorders (NCD). Concretely, to assess the effects of individual CS on global cognition, and mood, as well as to analyze neuronal activity with oxygenation, volume and blood flow in the brain, evaluating the impact of cognitive stimulation on brain hemodynamics. Participants in the intervention group receive two 45 min-session of CS per week for 12 weeks in addition to their treatment as usual. Participants in the control group will maintain their treatment as usual.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effectiveness of a Cognitive Stimulation Program in Older Adults with Mild Neurocognitive Disorder: Insights from fNIRS Analysis in a Randomized Controlled Trial.
Justo-Henriques SI, Silva RCG, Carvalho JO, Apóstolo JLA, et al · · 2025 · PMID 40710911 · DOI 10.3390/neurolint17070108
Verify or expand the search:
- PubMed search for NCT04693611
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Individual cognitive stimulation therapy (iCST)
Trials testing the same drug.
- NCT04783285 — Effect of Individual Cognitive Stimulation at Home in Adults With Psychotic Disorders · NA · completed
Other recruiting trials for Dementia
Currently open trials in the same condition.
- NCT07531589 — BrainLive Connect: Non-professional Delivered CST for People Living With Dementia · NA · recruiting
- NCT07290387 — Tele-Savvy for Latino Caregivers · NA · recruiting
- NCT06088810 — The Impact of Music Intervention on Sleep · NA · recruiting
- NCT07482800 — Dementia in Fiction and Clinical Narratives · recruiting
- NCT07392944 — Multicomponent Exercise Program on Physical Function, Cognition and Falls Risk Among Older Adults Living in Nursing Home · NA · recruiting
Other CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas trials
Trials by the same sponsor.
- NCT04783285 — Effect of Individual Cognitive Stimulation at Home in Adults With Psychotic Disorders · NA · completed
- NCT04417751 — Care at 360º: A Long-term Individual Cognitive Stimulation Program · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04693611 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas
- Last refreshed: 1 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04693611.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing