NCT04691128 is a NA clinical trial of Desflurane in Supratentorial Tumor, sponsored by Beijing Tiantan Hospital.

Who is sponsoring NCT04691128?

NCT04691128 is sponsored by Beijing Tiantan Hospital.

What drugs are being tested in NCT04691128?

Interventions in NCT04691128: Desflurane, Propofol.

What condition does NCT04691128 study?

NCT04691128 studies Supratentorial Tumor.

Is NCT04691128 still recruiting?

NCT04691128 is currently completed. Last updated 26 October 2021.

Last reviewed 2021-10-26 · How we verify

NCT04691128

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Desflurane and Brain Relaxation in Craniotomy

Completed NA Last updated 26 October 2021

What this trial tests

NA trial testing Desflurane in Supratentorial Tumor in 111 participants. Completed in 31 August 2021.

Timeline

26 January 2021

Primary endpoint
30 August 2021

31 August 2021

Quick facts

Lead sponsor	Beijing Tiantan Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	111
Start date	26 January 2021
Primary completion	30 August 2021
Estimated completion	31 August 2021
Sites	1 location across China

Drugs / interventions tested

Desflurane (DESFLURANE) — full drug profile →
Propofol (Propofol) — full drug profile →

Conditions studied

Supratentorial Tumor — all drugs for Supratentorial Tumor →

Sponsor

Beijing Tiantan Hospital

Who can join

Adults 18 to 60, any sex, with Supratentorial Tumor. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Optional brain relaxation improves the surgeon's operating conditions and is likely to minimize the degree of retraction injury ,with the potential for providing patients with a better outcome. The choice of anesthetic drugs can affect intraoperative brain relaxation. Propofol suppresses brain metabolism, reduces cerebral blood flow, and provides satisfactory brain relaxation. Desflurane is often criticized in neurosurgery due to its cerebral vasodilation and potential to increase intracranial pressure, however, it has been found to have a little clinical significance. This study intends to compare the effects of desflurane with propofol on brain relaxation in patients with supratentorial tumors under mild hyperventilation, and to provide new clinical evidence for the use of desflurane in neurosurgical anesthesia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Brain relaxation using desflurane anesthesia and total intravenous anesthesia in patients undergoing craniotomy for supratentorial tumors: a randomized controlled study.
Jiang Z, Wu Y, Liang F, Jian M, et al · · 2023 · cited 8× · PMID 36624384 · DOI 10.1186/s12871-023-01970-z

Verify or expand the search:

Other trials of Desflurane

Trials testing the same drug.

NCT07525648 — Comparison of the Effects of Sevoflurane and Desflurane on Optic Nerve Sheath Diameter During Laparoscopic Surgery · NA · recruiting
NCT07511634 — Comparison of Sevoflurane and Desflurane on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Cont · NA · not yet recruiting
NCT07440758 — Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy · NA · not yet recruiting
NCT07295158 — Effect of Sevoflurane vs Desflurane on Mechanical Power in Laparoscopic Cholecystectomy · NA · recruiting
NCT07123870 — Effect of Combined Intravenous-Inhalational Anesthesia (CIVIA) on Postoperative Recovery Patterns. · Phase 4 · recruiting

Other Beijing Tiantan Hospital trials

Trials by the same sponsor.

NCT07341854 — Dexamethasone Palmitate for Postoperative Pain · NA · not yet recruiting
NCT07527013 — Stratified Blood Pressure Management Strategy After Endovascular Treatment for Acute Ischemic Stroke · Phase 3 · not yet recruiting
NCT07520370 — Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor · NA · not yet recruiting
NCT07526987 — Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis · Phase 3 · not yet recruiting
NCT07591207 — The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04691128 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beijing Tiantan Hospital
Last refreshed: 26 October 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04691128.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing