NCT04691037: CICM-SCP

CCTA Improves Clinical Management of Stable Chest Pain

Recruiting now Last updated 28 March 2024

What this trial tests

trial testing CCTA in Coronary Computed Tomography Angiography in 50,000 participants. Currently enrolling.

Timeline

1 January 2016

Primary endpoint
1 January 2030

1 January 2030

Quick facts

Lead sponsor	Tianjin Chest Hospital
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	50,000
Start date	1 January 2016
Primary completion	1 January 2030
Estimated completion	1 January 2030
Sites	4 locations across China

Drugs / interventions tested

• CCTA

Conditions studied

• Coronary Computed Tomography Angiography — all drugs for Coronary Computed Tomography Angiography →
• Stable Chest Pain — all drugs for Stable Chest Pain →
• Optimal Medical Therapy — all drugs for Optimal Medical Therapy →
• Invasive Coronary Angiography — all drugs for Invasive Coronary Angiography →

Sponsor

Tianjin Chest Hospital

Who can join

18 and older, any sex, with Coronary Computed Tomography Angiography or Stable Chest Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. This study will determine if CCTA-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. Association between Coronary Artery Disease Reporting and Data System-recommended Post-Coronary CT Angiography Management and Clinical Outcomes in Patients with Stable Chest Pain from a Chinese Registry.
   Zhou J, Li C, Zhang H, Liu C, et al · · 2023 · cited 8× · PMID 37310243 · DOI 10.1148/radiol.222965
2. Identification of vulnerable non-culprit lesions by coronary computed tomography angiography in patients with chronic coronary syndrome and diabetes mellitus.
   Zhao J, Zhang H, Liu C, Zhang Y, et al · · 2023 · cited 3× · PMID 37034343 · DOI 10.3389/fcvm.2023.1143119
3. Validation and Comparison of PROMISE and CONFIRM Model to Predict High-Risk Coronary Artery Disease in Symptomatic and Diabetes Mellitus Patients.
   Jiang H, Feng J, Feng C, Ren P, et al · · 2022 · cited 3× · PMID 35345247 · DOI 10.31083/j.rcm2303080
4. Coronary Artery Calcium Score Improves Risk Assessment of Symptomatic Patients in Low-Risk Group Based on Current Guidelines.
   Wang C, Zhang X, Liu C, Zhang C, et al · · 2023 · cited 1× · PMID 39077531 · DOI 10.31083/j.rcm2406162
5. Comparison of the RF-CL and CACS-CL models to estimate the pretest probability of obstructive coronary artery disease and predict prognosis in patients with stable chest pain and diabetes mellitus.
   Chen T, Shao D, Zhao J, Xiu M, et al · · 2024 · cited 1× · PMID 38586168 · DOI 10.3389/fcvm.2024.1368743
6. Comparison of coronary artery calcium score-based and all-coronary computed tomography angiography strategies in patients with stable chest pain and risk factor-weighted clinical likelihood of 5-15.
   Wang P, Chen T, He M, Xin T, et al · · 2026 · PMID 41721263 · DOI 10.1186/s12880-026-02232-3
7. Coronary Artery Calcium Score-Weighted Clinical Likelihood Model Performance in Patients with Stable Chest Pain and Coronary Artery Calcium Scores of Zero.
   Tan Y, Liu C, Chen T, Li Y, et al · · 2024 · PMID 39076944 · DOI 10.31083/j.rcm2503085