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NCT04689438
GCF Levels of IL-1β and IL-6 in Gingivitis and Stage III-Grade C Periodontitis
trial testing gingival crevicular fluid in Periodontitis in 64 participants. Completed in 28 December 2020.
25 December 2020
Quick facts
| Lead sponsor | Uşak University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 64 |
| Start date | 8 October 2020 |
| Primary completion | 25 December 2020 |
| Estimated completion | 28 December 2020 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- gingival crevicular fluid
Conditions studied
- Periodontitis — all drugs for Periodontitis →
Sponsor
Uşak University
Who can join
Adults 20 to 65, any sex, with Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Periodontal diseases are chronic diseases that occur as a result of a violation of the balance between microbial dental plaque and the host response. Gingivitis is a disease characterized by inflammation of the gingiva that occurs in one or more areas without loss of attachments.1 in periodontitis, an inflammatory event that begins in the gingiva along with gingivitis spreads to the periodontal ligament, alveolar bone and soft tissues that support the tooth, causing the destruction of these structures.2 Cytokines are low molecular weight proteins that participate in the initial and active stages of inflammation and immunity. In periodontal disease pathogenesis, cytokine response has been reported to play a very critical role in determining disease progression.3 IL-1beta and IL-6 are key cytokines in chronic inflammatory diseases and have the potential to initiate bone loss and tissue destruction seen in periodontal disease.4the purpose of this study; it is to determine the degree of inflammation and periodontal destruction by determining the levels of IL-1beta and IL-6 cytokines in the gingival crevicular fluid of periodontal healthy and diseased individuals.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04689438
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of gingival crevicular fluid
Trials testing the same drug.
- NCT05568290 — Interleukin-38 Levels in Individuals With Periodontitis · unknown
- NCT04850768 — (NOD)-Like Receptors CARD Domain-Containing 4 Levels in Individuals With Periodontitis · unknown
- NCT04402996 — Meteorin-like Levels in Individuals With Periodontitis · completed
Other recruiting trials for Periodontitis
Currently open trials in the same condition.
- NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
- NCT07535177 — Gas6 and Soluble MerTK in Periodontal Diseases · recruiting
- NCT07491848 — Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D · recruiting
- NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
- NCT07532694 — Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients · NA · recruiting
Other Uşak University trials
Trials by the same sponsor.
- NCT07356362 — High-power Laser Therapy for Notalgia Paresthetica. · NA · not yet recruiting
- NCT07328360 — The Efficacy of High-Power Laser Therapy in Meralgia Paresthetica · NA · recruiting
- NCT07276477 — Inspiratory Muscle Training After Stroke · NA · recruiting
- NCT07296380 — Manual Therapy Behavior Scale in Physiotherapists · enrolling by invitation
- NCT07296367 — Physiotherapy and Disaster · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04689438 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Uşak University
- Last refreshed: 4 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04689438.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing