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NCT04688645
Balanced Crystalloid Solutions for Acute Pancreatitis
Phase 4 trial testing Balanced crystalloid solution in Acute Pancreatitis in 276 participants. Status unknown.
1 December 2022
Quick facts
| Lead sponsor | University Hospital Rijeka |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 276 |
| Start date | 1 May 2020 |
| Primary completion | 1 December 2022 |
| Estimated completion | 1 February 2023 |
| Sites | 1 location across Croatia |
Drugs / interventions tested
- Balanced crystalloid solution
- Normal saline
Conditions studied
- Acute Pancreatitis — all drugs for Acute Pancreatitis →
Sponsor
University Hospital Rijeka
Who can join
18 and older, any sex, with Acute Pancreatitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Patients diagnosed with acute pancreatitis regardless of etiology, severity of disease, and prior attacks will be randomized in two groups. The intervention group will receive a balanced crystalloid (Plasmalyte) at a rate of 10 ml/kg during the first 60 min and then continued at 3 ml/kg/h for the next 72 hours. The control group will receive normal saline at the same rate.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Intravenous fluid therapy in patients with severe acute pancreatitis admitted to the intensive care unit: a narrative review.
Crosignani A, Spina S, Marrazzo F, Cimbanassi S, et al · · 2022 · cited 44× · PMID 36251136 · DOI 10.1186/s13613-022-01072-y
Verify or expand the search:
- PubMed search for NCT04688645
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Balanced crystalloid solution
Trials testing the same drug.
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- NCT05386953 — Intraoperative Normal Saline Administration and Acute Kidney Injury in Patients Undergoing Liver Transplantation · unknown
- NCT04540094 — Feasibility of 5% Albumin Compared With Balanced Crystalloid, as Intravenous Fluid Resuscitation in Adult Patients With · Phase 3 · completed
- NCT02835157 — Balanced Crystalloid vs. Saline in Children With Septic Shock · NA · completed
Other recruiting trials for Acute Pancreatitis
Currently open trials in the same condition.
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- NCT03547232 — Rectal Indomethacin as Early Treatment for Acute Pancreatitis (INDOMAP Trial) · Phase 4 · recruiting
- NCT06401577 — Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics · recruiting
Other University Hospital Rijeka trials
Trials by the same sponsor.
- NCT06236360 — Metastatic Melanoma Patients on Immunotherapy With Nutritive Intervention Based on Mediterranean Diet · NA · unknown
- NCT04760353 — The Effect of a Probiotic Mixture in Obese Patients With Irritable Bowel Syndrome · NA · completed
- NCT04532476 — Effect of a Double Dose of Photobiomodulaton Therapy on Orthodonthic Pain Caused by Elastomeric Separators · NA · completed
- NCT03530189 — Outcome of Very Preterm Infants With Glucose Level Disturbances · completed
- NCT04038853 — Vitamin D in Fatty Liver Disease · Phase 4 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04688645 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital Rijeka
- Last refreshed: 30 December 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04688645.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing