Last reviewed · How we verify
NCT04688190: CHOICE-MI
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
trial in Mitral Regurgitation in 800 participants. Currently enrolling.
1 March 2025
Quick facts
| Lead sponsor | Universitätsklinikum Hamburg-Eppendorf |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 800 |
| Start date | 1 November 2020 |
| Primary completion | 1 March 2025 |
| Estimated completion | 31 December 2030 |
| Sites | 26 locations across Denmark, France, Italy, United Kingdom, Germany, Norway, Canada, Switzerland |
Conditions studied
- Mitral Regurgitation — all drugs for Mitral Regurgitation →
Sponsor
Universitätsklinikum Hamburg-Eppendorf — full company profile →
Who can join
18 and older, any sex, with Mitral Regurgitation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This multinational, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent transcatheter mitral valve implantation (TMVI), in comparison to those screened for TMVI but deemed ineligible, who subsequently underwent interventional mitral valve edge-to-edge repair, mitral valve surgery or medical/conservative therapy.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Clinical outcomes of transcatheter mitral valve replacement: two-year results of the CHOICE-MI Registry.
Ludwig S, Perrin N, Coisne A, Ben Ali W, et al · · 2023 · cited 27× · PMID 37235388 · DOI 10.4244/eij-d-22-01037 -
Transcatheter Mitral Valve Replacement Versus Medical Therapy for Secondary Mitral Regurgitation: A Propensity Score-Matched Comparison.
Ludwig S, Conradi L, Cohen DJ, Coisne A, et al · · 2023 · cited 15× · PMID 37194288 · DOI 10.1161/circinterventions.123.013045 -
Outcomes Following Transcatheter Mitral Valve Replacement Using Dedicated Devices in Patients With Mitral Annular Calcification.
Coisne A, Ludwig S, Scotti A, Ben Ali W, et al · · 2024 · cited 14× · PMID 39243262 · DOI 10.1016/j.jcin.2024.07.038 -
Management of patients with mitral regurgitation ineligible for standard therapy undergoing TMVI screening.
Ludwig S, Sedighian R, Weimann J, Koell B, et al · · 2022 · cited 11× · PMID 34992049 · DOI 10.4244/eij-d-21-00708 -
Challenges and Open Issues in Transcatheter Mitral Valve Implantation: Smooth Seas Do Not Make Skillful Sailors.
Russo G, Maisano F, Massaro G, Terlizzese G, et al · · 2021 · cited 8× · PMID 35224022 · DOI 10.3389/fcvm.2021.738756 -
Phenotypic clustering analysis of patients rejected for mitral valve interventions: implications for future transcatheter technologies.
Ludwig S, Coisne A, Hamzi K, Ben Ali W, et al · · 2025 · cited 2× · PMID 40329826 · DOI 10.1093/ehjci/jeaf141
Verify or expand the search:
- PubMed search for NCT04688190
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Mitral Regurgitation
Currently open trials in the same condition.
- NCT07450911 — A Clinical Study Evaluating the Replacement of the Native Mitral Valve Using the ReValve System · Phase 1 · recruiting
- NCT07366723 — The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgurgitation · NA · active not recruiting
- NCT07007143 — STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication fo · Phase 4 · recruiting
- NCT07108907 — Outcome Registry and Assessment of New Edge-to-Edge Repair · recruiting
- NCT06901466 — STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indication for O · Phase 4 · recruiting
Other Universitätsklinikum Hamburg-Eppendorf trials
Trials by the same sponsor.
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- NCT07009522 — Hamburg Emotion Awareness and Regulation Group Training for Autistic Adolescents (HEART) · EARLY_PHASE1 · not yet recruiting
- NCT07115394 — EEG Measurements to Capture DBS-induced Electric Potentials · recruiting
- NCT06955884 — Patient Experience of Transoral Versus Transnasal Awake Tracheal Intubation · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04688190 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universitätsklinikum Hamburg-Eppendorf
- Last refreshed: 17 May 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04688190.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing