NCT04686955 is a Phase 3 clinical trial of Xiao-Xian-Gui-Fu-Tang in Atopic Dermatitis, sponsored by Taipei Veterans General Hospital, Taiwan.

Who is sponsoring NCT04686955?

NCT04686955 is sponsored by Taipei Veterans General Hospital, Taiwan.

What drugs are being tested in NCT04686955?

Interventions in NCT04686955: Xiao-Xian-Gui-Fu-Tang, Placebo.

What condition does NCT04686955 study?

NCT04686955 studies Atopic Dermatitis.

Is NCT04686955 still recruiting?

NCT04686955 is currently completed. Last updated 24 November 2025.

Last reviewed 2025-11-24 · How we verify

NCT04686955

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Efficacy of Patients With Moderate to Severe Atopic Dermatitis Treated With Chinese Herbal Medicine

Completed Phase 3 Last updated 24 November 2025

What this trial tests

Phase 3 trial testing Xiao-Xian-Gui-Fu-Tang in Atopic Dermatitis in 19 participants. Completed in 31 December 2022.

Timeline

25 January 2021

Primary endpoint
31 December 2022

31 December 2022

Quick facts

Lead sponsor	Taipei Veterans General Hospital, Taiwan
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	treatment
Enrollment	19
Start date	25 January 2021
Primary completion	31 December 2022
Estimated completion	31 December 2022
Sites	2 locations across Taiwan

Drugs / interventions tested

Xiao-Xian-Gui-Fu-Tang — full drug profile →
Placebo

Conditions studied

Atopic Dermatitis — all drugs for Atopic Dermatitis →

Sponsor

Taipei Veterans General Hospital, Taiwan

Who can join

Adults 6 to 30, any sex, with Atopic Dermatitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Conduct a clinical trial of integration of Chinese and Western medicine to evaluate whether the association of traditional Chinese medicine therapy has a remission effect on atopic dermatitis, and to explore the remission of lesions after an association of Chinese herbal medicine, and the correlation of syndrome differentiation types before and after treatment with Chinese and Western medicine, with a view to better understand the efficacy of atopic dermatitis in the treatment of the same disease in Traditional Chinese Medicine, and provide another option for patients with atopic dermatitis.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Adjunctive Use of VGH4 for Moderate-to-Severe Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Trial.
Liao YJ, Wu TP, Lai CC, Kung YY, et al · · 2026 · PMID 42073486 · DOI 10.3390/life16040680
Antimicrobial and Anti-Infective Potential of Herbal Creams in Dermatology: Efficacy, Safety, and Challenges in Skin Infection Management.
Brar GS, Nandy SK, Sharma A, Siddiqui AJ, et al · · 2025 · PMID 41362433 · DOI 10.2147/idr.s565852

Verify or expand the search:

Other recruiting trials for Atopic Dermatitis

Currently open trials in the same condition.

NCT07262983 — Evaluating the Safety and Tolerability of Baricitinib in Patients With Job Syndrome With Lupus-Like Disease and/or Atopi · Phase 1 · recruiting
NCT07445919 — A Clinical Study to Evaluate SM17 for Atopic Dermatitis · Phase 2 · recruiting
NCT07488065 — A Study of SKB575 (HBM7575) Injection in Healthy Participants and Atopic Dermatitis Participants · Phase 1 · recruiting
NCT07467564 — The Impact of Dupilumab Treatment on Anxiety and Depression Symptoms in Patients With Moderate-to-Severe Atopic Dermatit · recruiting
NCT07358156 — A Study to Compare the Pharmacokinetics, Pharmacodynamic, Immunogenicity, and Safety of CKD-706 With US-Dupixent®, and E · Phase 1 · recruiting

Other Taipei Veterans General Hospital, Taiwan trials

Trials by the same sponsor.

NCT07463443 — Effectiveness of Chatbot for Improving Caregiving Outcomes in Primary Caregivers of Geriatric Pneumonia Patients: A Stud · NA · not yet recruiting
NCT07400757 — Statin and Vitamin D Treatment in Patients With Thyroid Eye Disease · NA · not yet recruiting
NCT07362134 — Pulsed-Field Ablation for Recurrent Atypical Atrial Flutter · NA · enrolling by invitation
NCT07473687 — Feasibility Study of Non-Contact Imaging-Based Physiological Monitoring in the Operating Room · recruiting
NCT07344207 — GUARD-PH: Guided Use of AI-ECG for Risk Detection of PH in Surgery (GUARD-PH Trial) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04686955 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Taipei Veterans General Hospital, Taiwan
Last refreshed: 24 November 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04686955.

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