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NCT04686253: IMPORT
Internal Microstructure of Patent Foramen Ovale Related to Stroke
trial testing not appliable in Patent Foramen Ovale in 1,200 participants. Currently enrolling.
31 December 2028
Quick facts
| Lead sponsor | China National Center for Cardiovascular Diseases |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 1,200 |
| Start date | 23 December 2020 |
| Primary completion | 31 December 2028 |
| Estimated completion | 31 December 2028 |
| Sites | 2 locations across China |
Drugs / interventions tested
- not appliable
Conditions studied
- Patent Foramen Ovale — all drugs for Patent Foramen Ovale →
Sponsor
China National Center for Cardiovascular Diseases — full company profile →
Who can join
Adults 16 to 65, any sex, with Patent Foramen Ovale. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these patients; (2) evaluate the microstructural features of asymptomatic patients with PFO and make a follow-up；(3) perform an untargeted metabolomics analysis using plasma samples from right atrium and left atrium and shunt provocative test was conducted;(4) collect the blood sample from PFO tunnel;(5) cardiac CTA was performed to evaluate the position and morphology of device.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Frequency and Size of In Situ Thrombus Within Patent Foramen Ovale.
Yan C, Li H, Wang C, Yu H, et al · · 2023 · cited 24× · PMID 36891906 · DOI 10.1161/strokeaha.122.041524
Verify or expand the search:
- PubMed search for NCT04686253
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Patent Foramen Ovale
Currently open trials in the same condition.
- NCT07170176 — Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine · NA · recruiting
- NCT05907694 — Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure · NA · recruiting
- NCT06953622 — Establishment of a Clinical and Prognostic Follow-up Cohort of Migraine Patients With Patent Foramen Ovale · recruiting
- NCT06156670 — Russian Registry of Endovascular Closure of PFO · recruiting
- NCT05387954 — PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years · Phase 3 · recruiting
Other China National Center for Cardiovascular Diseases trials
Trials by the same sponsor.
- NCT07514988 — Sirolimus-Coated vs Paclitaxel-Coated DCBs in ACS Treatment · NA · not yet recruiting
- NCT07476456 — Skeletal Muscle Multi-omics Analysis and Risk Tailoring in Sudden Cardiac Death · not yet recruiting
- NCT07302659 — Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG · NA · recruiting
- NCT07482683 — Predicting Post-Cardiac Surgery Acute Kidney Disease: A Machine Learning Approach · not yet recruiting
- NCT06787430 — Effects of Nicorandil on Microvascular Dysfunction in Patients With STEMI Undergoing Primary PCI · Phase 4 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04686253 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by China National Center for Cardiovascular Diseases
- Last refreshed: 22 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04686253.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing