NCT04683783 (RENACI) is a clinical trial in Colonic Cancer, sponsored by Hospital Miguel Servet.

Who is sponsoring NCT04683783?

NCT04683783 is sponsored by Hospital Miguel Servet.

What condition does NCT04683783 study?

NCT04683783 studies Colonic Cancer, Rectal Cancer, Liver Metastases.

Is NCT04683783 still recruiting?

NCT04683783 is currently completed. Last updated 24 December 2020.

Last reviewed 2020-12-24 · How we verify

NCT04683783: RENACI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

National Registry of Liver First Approach

Completed Last updated 24 December 2020

What this trial tests

trial in Colonic Cancer in 168 participants. Completed in 30 November 2020.

Timeline

1 June 2019

Primary endpoint
30 November 2020

30 November 2020

Quick facts

Lead sponsor	Hospital Miguel Servet
Status	Completed
Study type	OBSERVATIONAL
Enrollment	168
Start date	1 June 2019
Primary completion	30 November 2020
Estimated completion	30 November 2020
Sites	1 location across Spain

Conditions studied

Colonic Cancer — all drugs for Colonic Cancer →
Rectal Cancer — all drugs for Rectal Cancer →
Liver Metastases — all drugs for Liver Metastases →

Sponsor

Hospital Miguel Servet

Who can join

18 and older, any sex, with Colonic Cancer or Rectal Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Liver metastases are present in 15-25% of patients with colorectal cancer at the time of diagnosis of the primary tumor, which is defined as synchronous liver metastases. Treatment for the potential cure of this disease includes surgical resection of both the primary tumor and liver metastases. The liver first approach was described by Mentha for patients with asymptomatic rectal tumors with with initially unresectable or borderline resectable liver metastases. There is little data in the scientific literature on how many patients scheduled for this strategy complete both surgeries and/or undergo the full chemo/radiation therapy.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Textbook outcomes in the liver-first approach for colorectal liver metastases: prospective multicentre analysis.
Ramia JM, Villodre-Tudela C, Falgueras-Verdaguer L, Zambudio-Carroll N, et al · · 2024 · cited 2× · PMID 38266122 · DOI 10.1093/bjsopen/zrad123
Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project).
Serradilla-Martín M, Serradilla-Martín M, Villodre C, Falgueras-Verdaguer L, et al · · 2024 · PMID 38730631 · DOI 10.3390/cancers16091676

Verify or expand the search:

Other recruiting trials for Colonic Cancer

Currently open trials in the same condition.

NCT05434026 — Chinese Colorectal Cancer Database · recruiting
NCT04084249 — ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial · NA · active not recruiting
NCT00600496 — A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-14288 · Phase 1 · active not recruiting

Other Hospital Miguel Servet trials

Trials by the same sponsor.

NCT06950905 — Contemplative Practice for Well-being and Self-Deconstruction in Women · NA · recruiting
NCT06904794 — Evaluation of the Gambling Habits of Adolescents and Young Adults Post-COVID-19 and Implementation of a Digital Escape R · NA · recruiting
NCT05956405 — Retraining of the Amygdala and Insula for the Treatment of Persistent Covid · NA · completed
NCT06656065 — IMR-Heart Trasplant Study · recruiting
NCT05317754 — Effectiveness of Four Deconstructive Meditative Practices on Well-being and Self-deconstruction · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04683783 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hospital Miguel Servet
Last refreshed: 24 December 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04683783.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing