Last reviewed · How we verify
Netrin-1 and Placenta Accreta
Netrin-1 is a secreted protein, which was first identified as a neuronal guidance factor. It is expressed in a multitude of tissues as pancreas, lung, breast, and placenta. Netrin-1 is a multifunctional protein, involved in cell polarity, adhesion, angiogenesis, apoptosis, migration, morphogenesis, and differentiation of various cell types. Most of netrin-1 activity occur through signaling pathways induced by its two main receptors, DCC (deleted in colorectal cancer) and UNC5H (uncoordinated-5 homolog). Its receptors have been linked to the processes of apoptosis and angiogenesis. In absence of netrin-1, DCC and UNC5H receptors lead to apoptosis. In contrary, in presence of netrin-1, receptors transduce molecular cascades leading to proliferation, differentiation and migration of the cells. Netrin-1 has been involved in the pathogenesis of multiple diseases, as diabetes, cardiovascular diseases, and cancer. Serum Netrin-1 levels were high in preeclamptic patients.
Details
| Lead sponsor | Assiut University |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 34 |
| Start date | Wed Dec 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Jun 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Placenta Accreta
Interventions
- Pregnant women at 28-32 weeks
- at delivery
Countries
Egypt