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NCT04681937
Comparison of Hyaluronic Acid, PRP and Steroid Injections in Partial Rotator Cuff Tears: A Prospective Randomized Study
NA trial testing Subacromial Injection (hyaluronic acid) + Physical Therapy. in Partial Tear of Rotator Cuff in 80 participants. Status unknown.
15 November 2021
Quick facts
| Lead sponsor | Bezmialem Vakif University |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 1 June 2021 |
| Primary completion | 15 November 2021 |
| Estimated completion | 15 September 2022 |
| Sites | 2 locations across Turkey (Türkiye) |
Drugs / interventions tested
- Subacromial Injection (hyaluronic acid) + Physical Therapy.
- Subacromial Injection (Platelet-Rich-Plasma) + Physical Therapy.
- Subacromial Injection (methylprednisolone acetate) + Physical Therapy.
- Subacromial Injection (Serum Saline) + Physical Therapy.
Conditions studied
- Partial Tear of Rotator Cuff — all drugs for Partial Tear of Rotator Cuff →
- Rotator Cuff Tears — all drugs for Rotator Cuff Tears →
Sponsor
Bezmialem Vakif University
Who can join
Adults 18 to 70, any sex, with Partial Tear of Rotator Cuff or Rotator Cuff Tears. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
There are many conservative treatment options available for partial rotator cuff tears. However, the superiority of a certain type of injection could not be demonstrated with the available data. Our aim is to compare the effectiveness of steroid, hyaluronic acid, prp and placebo (normal saline) injections in partial rotator cuff tears by applying the same physical therapy protocol after injection.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Clinical and Biochemical Implications of Hyaluronic Acid in Musculoskeletal Rehabilitation: A Comprehensive Review.
Iaconisi GN, Gallo N, Caforio L, Ricci V, et al · · 2023 · cited 14× · PMID 38138874 · DOI 10.3390/jpm13121647
Verify or expand the search:
- PubMed search for NCT04681937
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04681937 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Bezmialem Vakif University
- Last refreshed: 1 June 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04681937.
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