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NCT04681365: BubblePAPR
Evaluating Bubble-PAPR for Healthcare Workers
trial testing Staff will wear and evaluate Bubble-PAPR (non-CE marked PAPR) in Covid19 in 106 participants. Completed in 31 December 2021.
23 December 2021
Quick facts
| Lead sponsor | Manchester University NHS Foundation Trust |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 106 |
| Start date | 24 February 2021 |
| Primary completion | 23 December 2021 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Staff will wear and evaluate Bubble-PAPR (non-CE marked PAPR)
Conditions studied
- Covid19 — all drugs for Covid19 →
Sponsor
Manchester University NHS Foundation Trust
Who can join
Adults 18 to 70, any sex, with Covid19. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This project will produce a low cost, ergonomic, hood integrated PAPR for use initially within the NHS. It will focus on user centred design, engineering optimisation, feasibility testing, certification and intellectual property protection. This study will evaluate the pre-CE marked Bubble PAPR prototype PPE in the clinical environment and gather usability data from consenting participants (staff).
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Bubble-PAPR: a phase 1 clinical evaluation of the comfort and perception of a prototype powered air-purifying respirator for use by healthcare workers in an acute hospital setting.
McGrath BA, Shelton CL, Gardner A, Coleman R, et al · · 2023 · cited 3× · PMID 37156585 · DOI 10.1136/bmjopen-2022-066524 -
The carbon footprint of Bubble-PAPR™: A novel item of personal protective equipment.
Pinder A, Fang L, Hillson R, Steinbach I, et al · · 2024 · PMID 39323593 · DOI 10.1177/17511437231173349 -
Bubble-PAPR: Phase I clinical evaluation of an ‘in-house’ developed prototype powered air-purifying respirator for use by healthcare workers
McGrath BA, Shelton C, Gardner A, Coleman R, et al · · 2022 · DOI 10.1101/2022.07.14.22277643
Verify or expand the search:
- PubMed search for NCT04681365
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Manchester University NHS Foundation Trust trials
Trials by the same sponsor.
- NCT07057284 — DENTOFACIAL-PBT Stage 2 - Feasibility Study · enrolling by invitation
- NCT06972238 — Glucose Levels in Acute Pancreatitis and the Impact of Insulin Depletion and Bacterial Endotoxaemia · not yet recruiting
- NCT06681545 — Exploring the Lived Experience of Young Adults With Severe Asthma · recruiting
- NCT07049263 — Disparities In Access to the Northwest Ambulance Service During Pregnancy, Birth and Postpartum Period and Its Associati · active not recruiting
- NCT06561334 — Spasmodic Dysphonia Interviews · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04681365 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Manchester University NHS Foundation Trust
- Last refreshed: 20 January 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04681365.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing