NCT04675970 (UB-OVF) is a clinical trial of Observational in Primary Ovarian Insufficiency, sponsored by Ukraine Association of Biobank.

Who is sponsoring NCT04675970?

NCT04675970 is sponsored by Ukraine Association of Biobank.

What drugs are being tested in NCT04675970?

Interventions in NCT04675970: Observational.

What condition does NCT04675970 study?

NCT04675970 studies Primary Ovarian Insufficiency, Premature Ovarian Failure.

Is NCT04675970 still recruiting?

NCT04675970 is currently completed. Last updated 22 December 2025.

Last reviewed 2025-12-22 · How we verify

NCT04675970: UB-OVF

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy

Completed Last updated 22 December 2025

What this trial tests

trial testing Observational in Primary Ovarian Insufficiency in 86 participants. Completed in 30 September 2025.

Timeline

1 September 2020

Primary endpoint
30 September 2024

30 September 2025

Quick facts

Lead sponsor	Ukraine Association of Biobank
Status	Completed
Study type	OBSERVATIONAL
Enrollment	86
Start date	1 September 2020
Primary completion	30 September 2024
Estimated completion	30 September 2025
Sites	1 location across Ukraine

Drugs / interventions tested

Observational — full drug profile →

Conditions studied

Primary Ovarian Insufficiency — all drugs for Primary Ovarian Insufficiency →
Premature Ovarian Failure — all drugs for Premature Ovarian Failure →

Sponsor

Ukraine Association of Biobank

Who can join

Adults 18 to 40, female only, with Primary Ovarian Insufficiency or Premature Ovarian Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a multi-centers of long term safety and efficacy follow up study for patients with premature ovarian failure (the women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility) who have been treated with ex vivo gene therapy drug product in Institute of Bio-Stem Cell Rehabilitation UAB - sponsored clinical studies. After completing the parent clinical study (approximately 6 month), eligible subject will be followed for additional 2 years for total of 2 years and 6 month post drug product infusion. No investigation drug product will be administered in the study

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Bone marrow mesenchymal stem cells in premature ovarian failure: Mechanisms and prospects.
Huang Y, Zhu M, Liu Z, Hu R, et al · · 2022 · cited 20× · PMID 36389844 · DOI 10.3389/fimmu.2022.997808
Ovarian Aging: Mechanisms, Age-Related Disorders, and Therapeutic Interventions.
Liu X, Zhao Y, Feng Y, Wang S, et al · · 2025 · cited 3× · PMID 41256733 · DOI 10.1002/mco2.70481

Verify or expand the search:

Other trials of Observational

Trials testing the same drug.

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Other recruiting trials for Primary Ovarian Insufficiency

Currently open trials in the same condition.

NCT07357701 — Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI) · recruiting
NCT06357442 — Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Dail · recruiting
NCT06167135 — Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort · recruiting
NCT05327283 — Investigation of Copy Number Variations and Genetic Variants in POI · recruiting

Other Ukraine Association of Biobank trials

Trials by the same sponsor.

NCT07305480 — Longitudinal Clinical Observation of a Digital Twin Model for Blastocyst Evaluation in IVF Clinics · active not recruiting
NCT04642911 — Longterm Follow-up of Subjects With Diabetes 2 Type Treatment With ex Vivo Gene Therapy · active not recruiting
NCT05080465 — Long Term Follow up Mesenchymal Stem Cell Therapy for Patients Virus-related Liver Cirrhosis · Phase 3 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04675970 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ukraine Association of Biobank
Last refreshed: 22 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04675970.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing