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NCT04674241
Dexmedetomidine Alleviates Postoperative Delirium After Brain Tumor Resections
NA trial testing Dexmedetomidine in Dexmedetomidine in 260 participants. Completed in 28 January 2022.
31 December 2021
Quick facts
| Lead sponsor | Beijing Tiantan Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 260 |
| Start date | 18 January 2021 |
| Primary completion | 31 December 2021 |
| Estimated completion | 28 January 2022 |
| Sites | 2 locations across China |
Drugs / interventions tested
- Dexmedetomidine (dexmedetomidine) — full drug profile →
- 0.9% saline
Conditions studied
- Dexmedetomidine — all drugs for Dexmedetomidine →
- Postoperative Delirium — all drugs for Postoperative Delirium →
Sponsor
Beijing Tiantan Hospital
Who can join
18 and older, any sex, with Dexmedetomidine or Postoperative Delirium. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Postoperative delirium (POD) is a common complication, and the incidence rate is about 25% in non cardiac surgery. Previous studies have reported that the total incidence of neurological pod ranged from 10% to 22%. Dexmedetomidine (DEX) is an a-2 adrenergic agonist for sedation. This kind of drug has little effect on respiratory function, is easy to wake up and has analgesic effect. It is a commonly used perioperative adjuvant drug. However, for neurosurgical patients with brain tumors, the role of DEX in POD is not clear. The purpose of this study was to investigate the effect of DEX on POD in neurosurgical brain tumor surgery.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Dexmedetomidine administration during brain tumour resection for prevention of postoperative delirium: a randomised trial.
Li S, Li R, Li M, Cui Q, et al · · 2023 · cited 42× · PMID 36517290 · DOI 10.1016/j.bja.2022.10.041 -
Effect of dexmedetomidine on postoperative delirium in patients undergoing brain tumour resections: study protocol of a randomised controlled trial.
Wang D, Li R, Li S, Wang J, et al · · 2021 · cited 12× · PMID 34758995 · DOI 10.1136/bmjopen-2021-051584 -
Association between intraoperative hypotension during brain tumor resection and postoperative delirium: A secondary analysis of a randomized controlled trial.
Wu Y, Ren Y, Li S, Zeng M, et al · · 2025 · PMID 41160633 · DOI 10.1371/journal.pone.0334094
Verify or expand the search:
- PubMed search for NCT04674241
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Dexmedetomidine
Trials testing the same drug.
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- NCT07398066 — DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial) · NA · not yet recruiting
- NCT07377981 — An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyp · Phase 4 · not yet recruiting
- NCT07306702 — Dexmedetomidine-Enhanced PCIA After Lobectomy in Nicotine-Dependent Patients · Phase 4 · withdrawn
- NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
Other recruiting trials for Dexmedetomidine
Currently open trials in the same condition.
- NCT07508202 — Comparison of Post Operative Analgesia in Patients Undergoing Lower Abdominal Surgeries Receiving Ultrasound Guided Bloc · Phase 4 · recruiting
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Other Beijing Tiantan Hospital trials
Trials by the same sponsor.
- NCT07341854 — Dexamethasone Palmitate for Postoperative Pain · NA · not yet recruiting
- NCT07527013 — Stratified Blood Pressure Management Strategy After Endovascular Treatment for Acute Ischemic Stroke · Phase 3 · not yet recruiting
- NCT07520370 — Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor · NA · not yet recruiting
- NCT07526987 — Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis · Phase 3 · not yet recruiting
- NCT07591207 — The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04674241 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Beijing Tiantan Hospital
- Last refreshed: 4 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04674241.
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