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NCT04673032: RAPID

Radiofrequency (RF) Ablation Prospective Outcomes Study

Completed Results posted Last updated 15 April 2026
What this trial tests

trial testing Radiofrequency Ablation in Pain, Chronic in 298 participants. Completed in 7 February 2025.

Timeline
22 December 2020
Primary endpoint
7 February 2025
7 February 2025

Quick facts

Lead sponsorBoston Scientific Corporation
StatusCompleted
Study typeOBSERVATIONAL
Enrollment298
Start date22 December 2020
Primary completion7 February 2025
Estimated completion7 February 2025
Sites15 locations across Belgium, Italy, Netherlands, United States

Drugs / interventions tested

Conditions studied

Sponsor

Boston Scientific Corporation — full company profile →

Who can join

0 and older, any sex, with Pain, Chronic. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Patient Global Impression of Change (PGIC) Primary · 12-months post-procedure

Using the Patient Global Impression of Change (PGIC) Scale, subjects will rate themselves as: very much improved; much improved; minimally improved; no change; minimally worse; much worse; or very much worse compared with Baseline

GroupValue95% CI
Boston Scientific Radiofrequency Ablation Systems66
Boston Scientific Radiofrequency Ablation Systems78
Boston Scientific Radiofrequency Ablation Systems54
Boston Scientific Radiofrequency Ablation Systems13
Responder Rate Secondary · 12-months post-procedure

Percentage of subjects with a 30 percent or greater reduction from Baseline in targeted pain intensity

GroupValue95% CI
Boston Scientific Radiofrequency Ablation Systems135

Adverse events — posted to ClinicalTrials.gov

Time frame: From the time a subject signs the study Informed Consent through study completion or study withdrawal (up to 24 months).. Reporting threshold: 1%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Boston Scientific Radiofrequency Ablation Systems
Serious: 44/298 (15%)
Deaths: 0/298

Serious adverse events (52 terms)

ReactionSystemBoston Scientific Radiofre…
Atrial fibrillationCardiac disorders
PneumoniaInfections and infestations
Atrioventricular block completeCardiac disorders
Coronary Artery diseaseCardiac disorders
Acute kidney injuryRenal and urinary disorders
Abdominal infectionInfections and infestations
Abscess limbInfections and infestations
Arthritis bacterialInfections and infestations
Bacterial infectionInfections and infestations
Device related infectionInfections and infestations
DiverticulitisInfections and infestations
Gastrointestinal infectionInfections and infestations
Haematoma infectionInfections and infestations
Localised infectionInfections and infestations
MastitisInfections and infestations
MeningitisInfections and infestations
Post procedural pneumoniaInfections and infestations
Post Wound InfectionInfections and infestations
Acute myocardial infarctionCardiac disorders
Myocardial infarctionCardiac disorders
Ankle fractureInjury, poisoning and procedural complications
Hip FractureInjury, poisoning and procedural complications
OverdoseInjury, poisoning and procedural complications
Post Procedural complicationInjury, poisoning and procedural complications
SeromaInjury, poisoning and procedural complications

Most-reported serious reactions: Atrial fibrillation, Pneumonia, Atrioventricular block complete, Coronary Artery disease, Acute kidney injury, Abdominal infection, Abscess limb, Arthritis bacterial.

Data from ClinicalTrials.gov NCT04673032 adverse events section.

Sponsor's own description

The objective of this study is to compile real-world outcomes of Boston Scientific commercially approved radiofrequency (RF) ablation systems in the treatment of patients diagnosed with pain

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Assessment of real-world, prospective outcomes in patients treated with lumbar radiofrequency ablation for chronic pain (RAPID).
    Provenzano DA, Holt B, Danko M, Atallah J, et al · · 2025 · cited 4× · PMID 40342788 · DOI 10.1016/j.inpm.2025.100576
  2. Assessment of real-world, prospective outcomes in patients treated with cervical radiofrequency ablation for chronic pain (RAPID).
    Provenzano DA, Holt B, Danko M, Atallah J, et al · · 2025 · PMID 40896553 · DOI 10.1016/j.inpm.2025.100623

Verify or expand the search:

Other trials of Radiofrequency Ablation

Trials testing the same drug.

Other recruiting trials for Pain, Chronic

Currently open trials in the same condition.

Other Boston Scientific Corporation trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04673032.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing