Last reviewed · How we verify
NCT04666948: BENEFICIAL
Precision Dosing of Vancomycin in Critically Ill Children
Phase 4 trial testing vancomycin model-informed precision dosing in Vancomycin in 314 participants. Completed in 30 October 2024.
14 December 2023
Quick facts
| Lead sponsor | University Hospital, Ghent |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 314 |
| Start date | 28 December 2020 |
| Primary completion | 14 December 2023 |
| Estimated completion | 30 October 2024 |
| Sites | 7 locations across Belgium |
Drugs / interventions tested
- vancomycin model-informed precision dosing
- Vancomycin (vancomycin) — full drug profile →
Conditions studied
- Vancomycin — all drugs for Vancomycin →
Sponsor
University Hospital, Ghent
Who can join
Adults 0 Days to 15, any sex, with Vancomycin. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The overall objective of this project is to investigate the large-scale utility of MIPD of vancomycin at point-of-care in ICU children. This evaluation includes a comparison with the more standard approach on Clinical and patient-oriented measures.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
A multicentric, randomized, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children-BENEFICIAL trial.
De Cock PA, Colman R, Amza A, De Paepe P, et al · · 2024 · cited 2× · PMID 39390583 · DOI 10.1186/s13063-024-08512-z -
Bedside model-informed precision dosing of vancomycin in severely ill neonates and children in Belgium (the BENEFICIAL trial): a multicentre, randomised controlled trial.
De Cock PA, Colman R, Smits A, Piersigilli F, et al · · 2026 · PMID 41974145 · DOI 10.1016/s2352-4642(25)00385-2
Verify or expand the search:
- PubMed search for NCT04666948
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Vancomycin
Currently open trials in the same condition.
- NCT06426836 — Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO) · NA · recruiting
Other University Hospital, Ghent trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04666948 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Ghent
- Last refreshed: 16 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04666948.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing