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NCT04665726: Light4Deaf
Natural History Study of Usher Syndrome ( Light4Deaf )
trial in Usher Syndromes in 400 participants. Currently enrolling.
8 June 2022
Quick facts
| Lead sponsor | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 400 |
| Start date | 8 June 2017 |
| Primary completion | 8 June 2022 |
| Estimated completion | 8 June 2027 |
| Sites | 4 locations across France |
Conditions studied
- Usher Syndromes — all drugs for Usher Syndromes →
Sponsor
Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Who can join
Eligibility, any sex, with Usher Syndromes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Clinical centres in the LIGHT4DEAF consortium have developed and will continue to improve a reliable, early molecular diagnosis and protocols for full clinical characterisation of Usher syndrome, which will be valuable for the foreseen USH clinical trials. The clinical arm of the project aims at performing a deep-phenotyping of retinal degeneration, hearing loss, vestibular dysfunction, neurocognitive ability of subects with a molecular diagnosis of any Usher syndrome. Functional and structural parameters for retinal, auditory, and vestibular impairments are followed overtime to document the natural history of the disease and establish relevant clinical endpoint for disease progression that may be useful for future clinical trials.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Retinal Phenotype of Patients with CLRN1-Associated Usher 3A Syndrome in French Light4Deaf Cohort.
Smirnov VM, Nassisi M, Mohand-Saïd S, Bonnet C, et al · · 2022 · cited 3× · PMID 35481838 · DOI 10.1167/iovs.63.4.25
Verify or expand the search:
- PubMed search for NCT04665726
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Usher Syndromes
Currently open trials in the same condition.
- NCT05355415 — Adaptive Optics Imaging of Outer Retinal Diseases · recruiting
Other Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts trials
Trials by the same sponsor.
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- NCT04239196 — Efficacy of Tocilizumab for the Treatment of Acute AION Related to GCA · Phase 2 · unknown
- NCT04419285 — Mobility Protocol Adapted for Advanced Visually Impaired Subjects · NA · unknown
- NCT04360291 — Impact of Visual Field Restriction on Visual Exploration · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04665726 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
- Last refreshed: 14 December 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04665726.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing