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NCT04663165
Biomarkers for Periodontitis Relapse
NA trial testing Periodontal surgery in Periodontitis in 21 participants. Completed in 12 January 2015.
23 September 2013
Quick facts
| Lead sponsor | Anders Holmlund |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 21 |
| Start date | 4 February 2010 |
| Primary completion | 23 September 2013 |
| Estimated completion | 12 January 2015 |
| Sites | 2 locations across Sweden |
Drugs / interventions tested
- Periodontal surgery
- Regenerative periodontal surgery
Conditions studied
- Periodontitis — all drugs for Periodontitis →
Sponsor
Anders Holmlund
Who can join
Eligibility, any sex, with Periodontitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this clinical study, we have collected GCF at diseased teeth and at the same time drawn blood, both before and at 3, 6 and 12 months after periodontal surgical treatment. This give us the opportunity to investigate if periodontal treatment could reduce inflammatory biomarkers in the systemic circulation and if there is a co-variation between biomarkers in GCF and blood. In part I of this study, we focus on biomarkers from blood serum in patients with periodontitis, before surgical therapy and under a healing period 12 months. In part II, biomarkers in the locally collected GCF will be analyzed together with clinically reported measurements and compared with biomarkers in blood serum. Hypothesis are * Periodontal treatment followed by clinical healing and periodontal health will be associated a change/ reduction in biomarkers in GCF. * The systemic levels of inflammatory biomarkers may show a delayed response to clinical healing. Periodontal surgical therapy may reduce circulating inflammatory biomarkers that could affect the low-grade chronic inflammation. * There is a co-variation between inflammatory biomarkers in GCF and the systemic circulation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04663165
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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- NCT03241953 — COMPARISION OF DIFFERENT TREATMENT METHODS OF PERI-IMPLANTITIS · NA · completed
- NCT03590093 — Amelogenins and Systemic Inflammation After Periodontal Surgical Therapy · NA · completed
Other recruiting trials for Periodontitis
Currently open trials in the same condition.
- NCT07463859 — Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabet · NA · recruiting
- NCT07535177 — Gas6 and Soluble MerTK in Periodontal Diseases · recruiting
- NCT07491848 — Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D · recruiting
- NCT07421960 — Investigation of the Relationship Between Periodontitis and Sleep Quality · recruiting
- NCT07532694 — Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04663165 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Anders Holmlund
- Last refreshed: 10 December 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04663165.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing