NCT04656197 is a clinical trial of Ocular microbiome in Dry Eye Disease, sponsored by Insel Gruppe AG, University Hospital Bern.

Who is sponsoring NCT04656197?

NCT04656197 is sponsored by Insel Gruppe AG, University Hospital Bern.

What drugs are being tested in NCT04656197?

Interventions in NCT04656197: Ocular microbiome.

What condition does NCT04656197 study?

NCT04656197 studies Dry Eye Disease.

Is NCT04656197 still recruiting?

NCT04656197 is currently completed. Last updated 7 December 2020.

Last reviewed 2020-12-07 · How we verify

NCT04656197

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Ocular Microbiome in Patients With Dry Eye Disease

Completed Last updated 7 December 2020

What this trial tests

trial testing Ocular microbiome in Dry Eye Disease in 80 participants. Completed in 4 March 2020.

Timeline

30 September 2019

Primary endpoint
4 March 2020

4 March 2020

Quick facts

Lead sponsor	Insel Gruppe AG, University Hospital Bern
Status	Completed
Study type	OBSERVATIONAL
Enrollment	80
Start date	30 September 2019
Primary completion	4 March 2020
Estimated completion	4 March 2020
Sites	1 location across Switzerland

Drugs / interventions tested

Ocular microbiome

Conditions studied

Dry Eye Disease — all drugs for Dry Eye Disease →

Sponsor

Insel Gruppe AG, University Hospital Bern

Who can join

60 and older, any sex, with Dry Eye Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary objective of this study is the characterization of the ocular microbiome in a healthy cohort and in patients with dry eye disease using whole-metagenome shotgun sequencing. Secondary objectives are the identification of differences between the ocular microbiome of healthy controls and patients with dry eye disease as well as between the ocular and the gut microbiome.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Understanding the Interactions Between the Ocular Surface Microbiome and the Tear Proteome.
Zysset-Burri DC, Schlegel I, Lincke JB, Jaggi D, et al · · 2021 · cited 26× · PMID 34369983 · DOI 10.1167/iovs.62.10.8
The Human Ocular Surface Microbiome and Its Associations with the Tear Proteome in Dry Eye Disease.
Schlegel I, De Goüyon Matignon de Pontourade CMF, Lincke JB, Keller I, et al · · 2023 · cited 21× · PMID 37762390 · DOI 10.3390/ijms241814091
Exploring the Ocular Surface Microbiome and Tear Proteome in Glaucoma.
Spörri L, Uldry AC, Kreuzer M, Herzog EL, et al · · 2024 · cited 17× · PMID 38892444 · DOI 10.3390/ijms25116257
Toward the Characterization of the Human Core Ocular Surface Microbiome.
Morandi SC, Uldry AC, Eldridge N, Kreuzer M, et al · · 2025 · cited 1× · PMID 40657968 · DOI 10.1167/iovs.66.9.40

Verify or expand the search:

Other trials of Ocular microbiome

Trials testing the same drug.

NCT04658238 — Ocular Microbiome and Immune System in Dry Eyes · recruiting

Other recruiting trials for Dry Eye Disease

Currently open trials in the same condition.

NCT06596733 — Vit-A-Vision® Clinical Investigation · NA · recruiting
NCT07264517 — Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED). · Phase 2 · recruiting
NCT07025811 — A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment · Phase 4 · recruiting
NCT04946721 — 2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD · recruiting
NCT06696625 — Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye · NA · recruiting

Other Insel Gruppe AG, University Hospital Bern trials

Trials by the same sponsor.

NCT06546384 — GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease · NA · not yet recruiting
NCT07524049 — Giving Children a Voice in Paediatric Anaesthesia · not yet recruiting
NCT07415668 — Motor Eloquent Navigated Transcranial Magnetic Stimulation for Radiosurgery Planning · NA · not yet recruiting
NCT07478536 — Stockholm3 Test Validation in Men on Active Surveillance in Switzerland (CHAS3 Trial) · not yet recruiting
NCT07201506 — Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04656197 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Insel Gruppe AG, University Hospital Bern
Last refreshed: 7 December 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04656197.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing