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NCT04652323
Tissue Reactions to Calcium Silicate
trial testing Biocompatibility of calcium silicate cements in Dental Materials in 24 participants. Completed in 1 August 2020.
1 April 2020
Quick facts
| Lead sponsor | Eskisehir Osmangazi University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 24 |
| Start date | 1 April 2019 |
| Primary completion | 1 April 2020 |
| Estimated completion | 1 August 2020 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Biocompatibility of calcium silicate cements — full drug profile →
Conditions studied
- Dental Materials — all drugs for Dental Materials →
- Mineral Trioxide Aggregate — all drugs for Mineral Trioxide Aggregate →
Sponsor
Eskisehir Osmangazi University
Who can join
Eligibility, any sex, with Dental Materials or Mineral Trioxide Aggregate. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study was to determine the subcutaneous connective tissue reactions to these new materials. Materials and Methods These materials were placed in polyethylene tubes and implanted into the dorsal connective tissue of Sprague Dawley rats. The presence of inflammation, edema, necrosis, dystrophic calcification, and thickness of fibrous capsule formation was recorded by histological examination 7, 30, and 60 days after the implantation procedure. Inflammation scores were defined as follows: 0 = no or few inflammatory cells, no reaction, 1 = \<25 cells, mild reaction; 2 = 25 to 125 cells, moderate reaction; and 3 = ≥125 cells, severe reaction. Fibrous capsule thickness, necrosis, and formation of calcification were recorded.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04652323
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04652323 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Eskisehir Osmangazi University
- Last refreshed: 3 December 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04652323.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing