Last reviewed · How we verify
NCT04649450: MUSYC
MusiC to Prevent deliriUm During neuroSurgerY
NA trial testing Music in Delirium in 189 participants. Status unknown.
9 July 2022
Quick facts
| Lead sponsor | Erasmus Medical Center |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 189 |
| Start date | 9 July 2020 |
| Primary completion | 9 July 2022 |
| Estimated completion | 9 March 2023 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Music
Conditions studied
- Delirium — all drugs for Delirium →
Sponsor
Erasmus Medical Center
Who can join
18 and older, any sex, with Delirium. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Rationale: Delirium is a common and severe complication after neurosurgical procedures. Music before, during and after surgical procedures has proven its effectiveness in reducing pain, anxiety, stress and opioid medication in surgical patients. These symptoms belong to the main eliciting factors for developing delirium. Effective preventive therapy for delirium is not available. The investigators hypothesize that music listening, being a sustainable intervention with negligible risk of side effects, can lower delirium incidence among neurosurgical patients, resulting in reduction of in-hospital stays, healthcare costs and post-operative morbidity and mortality. Objective: To assess the effect of peri-operative music on post-operative delirium in patients undergoing a craniotomy. Study design: Single-centre prospective randomized controlled trial. Study population: Adult patients undergoing a craniotomy at the Erasmus MC in Rotterdam. Intervention: Recorded music, with headphones or earphones, before, during and after surgery. Main study parameters/endpoints: Diagnosis of post-operative delirium screened by the DOS score confirmed by the consultant psychiatrist following the DSM-V criteria.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Music to prevent deliriUm during neuroSurgerY (MUSYC): a single-centre, prospective randomised controlled trial.
Kappen PR, Mos MI, Jeekel J, Dirven CMF, et al · · 2023 · cited 14× · PMID 37369412 · DOI 10.1136/bmjopen-2022-069957 -
Music to prevent deliriUm during neuroSurgerY (MUSYC) Clinical trial: a study protocol for a randomised controlled trial.
Kappen P, Jeekel J, Dirven CMF, Klimek M, et al · · 2021 · cited 5× · PMID 34598983 · DOI 10.1136/bmjopen-2020-048270 -
The effect of music interventions compared to standard-of-care on the prevention of delirium in neurosurgical patients: an analysis of costs and cost-effectiveness based on the MUSYC-trial.
Dirven TLA, Kappen PR, van der Beek FTH, van der Holt B, et al · · 2025 · cited 1× · PMID 39951210 · DOI 10.1007/s00701-025-06448-0
Verify or expand the search:
- PubMed search for NCT04649450
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT06539754 — Patient Satisfaction During Cesarean Delivery · NA · completed
- NCT06957990 — Evaluation of Music Therapy for Pre-op/Intra-op During Hernia Surgery to Decrease the Need for Narcotics · NA · enrolling by invitation
Other recruiting trials for Delirium
Currently open trials in the same condition.
- NCT07348471 — Fecal Microbiota Transplantation for the Treatment of ICU Delirium · NA · recruiting
- NCT06969287 — Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery · Phase 3 · recruiting
- NCT07369258 — Clinical Application of Listening to Music to Prevent Delirium in the Intensive Care Unit · NA · recruiting
- NCT07488468 — Quality Improvement Project to Reduce Preoperative Fasting Times Before Elective Procedures · recruiting
- NCT07136207 — Development and Validation of Delirium Recognition Using Computer Vision in Neuro-critical Patients · recruiting
Other Erasmus Medical Center trials
Trials by the same sponsor.
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- NCT07426575 — Evaluating the Usability of New Dialysis Bags · not yet recruiting
- NCT07329296 — The Regenerative Capacity of the Donor Liver After Living Donor Liver Transplantation: an Ambidirectional Cohort Study · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04649450 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Erasmus Medical Center
- Last refreshed: 2 December 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04649450.
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