NCT04646668 is a NA clinical trial of E-cigarette and Heat not burn in Tobacco Use Disorder, sponsored by University of Kansas Medical Center.

Who is sponsoring NCT04646668?

NCT04646668 is sponsored by University of Kansas Medical Center.

What drugs are being tested in NCT04646668?

Interventions in NCT04646668: E-cigarette and Heat not burn.

What condition does NCT04646668 study?

NCT04646668 studies Tobacco Use Disorder.

Is NCT04646668 still recruiting?

NCT04646668 is currently completed. Last updated 28 July 2023.

Are results published for NCT04646668?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2023-07-28 · How we verify

NCT04646668

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparative Abuse Liability Among African American and White Smokers

Completed NA Results posted Last updated 28 July 2023

What this trial tests

NA trial testing E-cigarette and Heat not burn in Tobacco Use Disorder in 22 participants. Completed in 26 August 2021.

Timeline

21 September 2020

Primary endpoint
26 August 2021

26 August 2021

Quick facts

Lead sponsor	University of Kansas Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	22
Start date	21 September 2020
Primary completion	26 August 2021
Estimated completion	26 August 2021
Sites	1 location across United States

Drugs / interventions tested

E-cigarette and Heat not burn

Conditions studied

Tobacco Use Disorder — all drugs for Tobacco Use Disorder →

Sponsor

University of Kansas Medical Center

Who can join

21 and older, any sex, with Tobacco Use Disorder. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Nicotine Delivery Primary · Baseline, after 10 puff bout of product at 5 minutes

Blood plasma nicotine concentration after 10 puff bout of product at 5 minutes

Group	Value	95% CI
Cigarette	14.13	4.3 – 35.6
E-Cigarette	6.79	0.5 – 26.6
Heat Not Burn	9.15	1.5 – 22.5

Sponsor's own description

The study is a randomized crossover trial. Current smokers will complete a session with each product: usual brand cigarette, e-cigarette, and heat-not-burn. The objective of this survey is to assess for ongoing use of study products and is part of safety monitoring.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Concurrent Choice Assessment of Preference and Substitutability of E-cigarettes and Heated Tobacco Products for Combustible Cigarettes Among African American and White Smokers.
Funk OL, Nollen NL, Wagener TL, Ahluwalia JS, et al · · 2023 · cited 6× · PMID 37042345 · DOI 10.1093/ntr/ntad052
The effect of nicotine delivery system on blood protease levels: a randomized crossover study.
Wilson AC, Leavens ELS, Covarrubias-Zambrano O, Lambart L, et al · · 2025 · PMID 41087506 · DOI 10.1038/s41598-025-19832-8

Verify or expand the search:

Other recruiting trials for Tobacco Use Disorder

Currently open trials in the same condition.

NCT07466875 — Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients · NA · recruiting
NCT06678672 — Contingency Management for Veteran Smokers Undergoing Major Elective Surgery · NA · recruiting
NCT06006143 — Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2 · Phase 2 · active not recruiting
NCT06883162 — Cannabis-Tobacco Co-Use Treatment Study · Phase 3 · recruiting
NCT06798324 — tDCS Plus Varenicline for Smoking Cessation · Phase 4 · recruiting

Other University of Kansas Medical Center trials

Trials by the same sponsor.

NCT06636214 — Adapting Changing Talk: Online (CHATO) to CHATO-Inclusive · NA · not yet recruiting
NCT07528963 — KanSurvive 2.0: Testing Enhanced Models of Cancer Survivorship Care for Rural Cancer Survivors in Primary Care Practice · NA · enrolling by invitation
NCT07463755 — Low-Fidelity Driving Simulator Training in Parkinson's Disease. · NA · not yet recruiting
NCT07420621 — Preliminary Effectiveness of Enhanced Text Message + Incentives · NA · recruiting
NCT07491510 — Improving Prenatal Care to Reduce Early Onset Preeclampsia in Low-Income · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04646668 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Kansas Medical Center
Last refreshed: 28 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04646668.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing