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NCT04645134: BrainFit
Physical Activity and Cognitive Function in Older Adults: A Novel Role for GPLD1
trial testing Brain Health Assessments in Aging in 25 participants. Completed in 17 March 2022.
17 March 2022
Quick facts
| Lead sponsor | Pennington Biomedical Research Center |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 25 |
| Start date | 1 April 2021 |
| Primary completion | 17 March 2022 |
| Estimated completion | 17 March 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Brain Health Assessments
Conditions studied
- Aging — all drugs for Aging →
- Cognitive Dysfunction — all drugs for Cognitive Dysfunction →
Sponsor
Pennington Biomedical Research Center — full company profile →
Who can join
Adults 65 to 85, any sex, with Aging or Cognitive Dysfunction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators are conducting a cross-sectional, observational study to investigate whether plasma GPLD1 concentrations are associated with higher cognitive function and better brain structure and function in two groups of older adults with high or low levels of physical activity.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Associations between physical activity, brain health, cognitive function, and circulating GPLD1 in healthy older (65-85 years) individuals.
Marlatt KL, Lowe AC, Sanchez-Delgado G, Beyl RA, et al · · 2025 · cited 2× · PMID 39762691 · DOI 10.1007/s11357-024-01459-8
Verify or expand the search:
- PubMed search for NCT04645134
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Pennington Biomedical Research Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04645134 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pennington Biomedical Research Center
- Last refreshed: 16 November 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04645134.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing