Last reviewed · How we verify
NCT04644887: LIDIGE
Liver, Diet and Genetic Background
NA trial testing Dietary intervention: Healthy diet in Liver Fat in 99 participants. Completed in 31 December 2021.
31 December 2021
Quick facts
| Lead sponsor | University of Eastern Finland |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 99 |
| Start date | 12 January 2021 |
| Primary completion | 31 December 2021 |
| Estimated completion | 31 December 2021 |
| Sites | 1 location across Finland |
Drugs / interventions tested
- Dietary intervention: Healthy diet
- Dietary intervention: Control diet
Conditions studied
- Liver Fat — all drugs for Liver Fat →
Sponsor
University of Eastern Finland
Who can join
Adults 60 to 75, male only, with Liver Fat. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
PNPLA3 rs738409 (I148M) variant is associated with hepatic liver accumulation and chronic liver diseases including non-alcoholic fatty liver disease. It has been shown that obesity augments genetic risk but studies investigating the interaction of PNPLA3 rs738409 risk variant and diet are scarce. The aim is to investigate the effect of dietary fat quality modification in participants with different variants of the PNPLA3 gene (rs738409). The primary outcome is the change in liver fat measured by magnetic resonance imaging in the randomized controlled 12-week dietary intervention trial.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
<i>PNPLA3</i> Genotype and Dietary Fat Modify Concentrations of Plasma and Fecal Short Chain Fatty Acids and Plasma Branched-Chain Amino Acids.
Tauriainen MM, Csader S, Lankinen M, Lo KK, et al · · 2024 · PMID 38257154 · DOI 10.3390/nu16020261
Verify or expand the search:
- PubMed search for NCT04644887
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Liver Fat
Currently open trials in the same condition.
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- NCT04899102 — Intermittent Fasting for NAFLD in Adults · NA · recruiting
Other University of Eastern Finland trials
Trials by the same sponsor.
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- NCT07430007 — Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass. · NA · recruiting
- NCT06923735 — Nutrition Apps in Occupational Healthcare (Pilot Study of the FOODNUTRI Project) · NA · enrolling by invitation
- NCT06495801 — Effectiveness of a Mobile Application in Improving Employees' Social Well-being. · NA · active not recruiting
- NCT06438276 — Psychiatric Outreach Nurses Supporting Adolescent Mental Health · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04644887 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Eastern Finland
- Last refreshed: 9 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04644887.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing