Who is sponsoring NCT04641949?

NCT04641949 is sponsored by Oslo University Hospital.

What drugs are being tested in NCT04641949?

Interventions in NCT04641949: Lower body negative pressure (LBNP).

What condition does NCT04641949 study?

NCT04641949 studies Hypovolemia, Cardiac Output, Low, Analgesia.

Is NCT04641949 still recruiting?

NCT04641949 is currently completed. Last updated 30 June 2022.

Last reviewed 2022-06-30 · How we verify

NCT04641949

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Methoxyflurane and Fentanyl in LBNP

Completed Phase 4 Last updated 30 June 2022

What this trial tests

Phase 4 trial testing Lower body negative pressure (LBNP) in Hypovolemia in 15 participants. Completed in 8 March 2022.

Timeline

18 November 2020

Primary endpoint
8 March 2022

8 March 2022

Quick facts

Lead sponsor	Oslo University Hospital
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	basic science
Enrollment	15
Start date	18 November 2020
Primary completion	8 March 2022
Estimated completion	8 March 2022
Sites	1 location across Norway

Drugs / interventions tested

Lower body negative pressure (LBNP)

Conditions studied

Hypovolemia — all drugs for Hypovolemia →
Cardiac Output, Low — all drugs for Cardiac Output, Low →
Analgesia — all drugs for Analgesia →

Sponsor

Oslo University Hospital

Who can join

Adults 18 to 65, any sex, with Hypovolemia or Cardiac Output, Low. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study is a single-centre, placebo-controlled, crossover study on healthy volunteers aiming to explore non-inferiority of methoxyflurane and fentanyl compared to placebo on the tolerance to hypovolemia.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Haemodynamic effects of methoxyflurane versus fentanyl and placebo in hypovolaemia: a randomised, double-blind crossover study in healthy volunteers.
Høiseth LØ, Fjose LO, Hisdal J, Comelon M, et al · · 2023 · cited 7× · PMID 37638077 · DOI 10.1016/j.bjao.2023.100204
Peripheral intravenous waveform analysis for evaluating volume status in healthy volunteers and mechanically ventilated patients.
Koistinaho A, Lie SL, Landsverk SA, Lenz H, et al · · 2026 · PMID 41609926 · DOI 10.1007/s10877-025-01408-6
Oslo HEMS Conference 2023
· 2023

Verify or expand the search:

Other trials of Lower body negative pressure (LBNP)

Trials testing the same drug.

NCT03354234 — Evaluation of the ORTHO-LBNP System · NA · completed

Other recruiting trials for Hypovolemia

Currently open trials in the same condition.

NCT07492511 — Renal and Hepatic Abnormal Doppler Patterns in Trauma · recruiting
NCT06591234 — Reliability of Internal Jugular Ultrasound : an Observational Transversal Study Conducted Using Images Registered From P · active not recruiting
NCT05931601 — Early Initiated Vasopressor Therapy in the Emergency Department · Phase 3 · recruiting

Other Oslo University Hospital trials

Trials by the same sponsor.

NCT07463885 — Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory Failure · NA · not yet recruiting
NCT07427719 — Retinopathy of Prematurity - Visual Function and Retinal Structure · not yet recruiting
NCT07403331 — Severe Chronic Neuropathic Pain: A Treatment Bundle, Using Spinal Cord Stimulation and Multidisciplinary Treatment, to R · NA · recruiting
NCT07449897 — Cholecystectomy With Intraoperative Management of Bile Duct Stones in Norway - the BILNOR Study · recruiting
NCT06173817 — The Use of Isocapnic Hyperventilation (iHV) for Treatment of Methanol Poisoned Patients · Phase 1 · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04641949 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Oslo University Hospital
Last refreshed: 30 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04641949.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing