NCT04641923 is a NA clinical trial of Adhesion barrier in Adhesion, sponsored by University of Calgary.

Who is sponsoring NCT04641923?

NCT04641923 is sponsored by University of Calgary.

What drugs are being tested in NCT04641923?

Interventions in NCT04641923: Adhesion barrier.

What condition does NCT04641923 study?

NCT04641923 studies Adhesion, Liver Neoplasms.

Is NCT04641923 still recruiting?

NCT04641923 is currently status unknown. Last updated 27 April 2021.

Last reviewed 2021-04-27 · How we verify

NCT04641923

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Efficacy of a Topical Anti-adhesive Film for Decreasing Perihepatic Adhesions in Repeat Hepatic Surgery

Status unknown NA Last updated 27 April 2021

What this trial tests

NA trial testing Adhesion barrier in Adhesion in 40 participants. Status unknown.

Timeline

1 November 2022

Primary endpoint
1 December 2024

1 June 2025

Quick facts

Lead sponsor	University of Calgary
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	40
Start date	1 November 2022
Primary completion	1 December 2024
Estimated completion	1 June 2025
Sites	1 location across Canada

Drugs / interventions tested

Adhesion barrier

Conditions studied

Adhesion — all drugs for Adhesion →
Liver Neoplasms — all drugs for Liver Neoplasms →

Sponsor

University of Calgary

Who can join

18 and older, any sex, with Adhesion or Liver Neoplasms. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Incidence of peri-hepatic adhesions at the time of repeat liver surgery
Time frame: 0-4 years from initial surgery, time of repeat surgery will vary from patient to patient
Evaluation will be performed at second surgery as follows: Calgary Scoring System Grade1-No adhesions, Grade2-Mild, Grade3-Moderate, Grade4-Severe adhesions, Grade5-severe adhesions with injury to other organs TORanomon Adhesion score (TORAD score): * Hepatic Hilum * 1-Easy: Easy for encircling the hepatoduodenal ligament (HDL) * 2-Hard: Additional maneuver for encircling HDL * 3-Extreme

Sponsor's own description

There has been an increase in the need for repeat hepatic surgery, especially for patients with colorectal liver metastasis and hepatocellular carcinoma. Adhesions at the time of repeat surgery can lead to increased operative times, higher blood loss and even increased perioperative morbidity. Not much data exists regarding use of anti-adhesion barriers at the time of index hepatectomy and their effect on adhesions at repeat hepatectomy. This randomized controlled trial aims to evaluate the effectiveness of the use of a hyaluronan and cellulose based antiadhesive topical film at index hepatectomy in reducing perihepatic adhesions at the time of repeat hepatic surgery.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Adhesion

Currently open trials in the same condition.

NCT03880435 — HYALOBARRIER® GEL ENDO Versus no HYALOBARRIER® GEL ENDO Following Operative Hysteroscopy for Improving Reproductive Outc · NA · active not recruiting

Other University of Calgary trials

Trials by the same sponsor.

NCT06885996 — Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence · Phase 2 · not yet recruiting
NCT05729503 — Effect of SPG Block for Patients With Anxiety at Electronic Dance Music Festivals · Phase 2 · not yet recruiting
NCT07463339 — Microbiome-guided Prophylaxis to Reduce Ventilator-Associated Pneumonia in Intensive Care Units: A Pilot Randomized Cont · Phase 2 · not yet recruiting
NCT07145645 — Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children · Phase 3 · recruiting
NCT07280325 — Moxie Self-Management and Education Support Program · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04641923 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Calgary
Last refreshed: 27 April 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04641923.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing