NCT04641533 is a NA clinical trial of L-PRF + DPSC in Stem Cell, sponsored by Baskent University.

Who is sponsoring NCT04641533?

NCT04641533 is sponsored by Baskent University.

What drugs are being tested in NCT04641533?

Interventions in NCT04641533: L-PRF + DPSC, L-PRF.

What condition does NCT04641533 study?

NCT04641533 studies Stem Cell, Third Molar, Periodontal Pocket.

Is NCT04641533 still recruiting?

NCT04641533 is currently completed. Last updated 24 November 2020.

Last reviewed 2020-11-24 · How we verify

NCT04641533

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Dental Pulp Stem Cells and L-PRF After Impacted Third Molar Extraction

Completed NA Last updated 24 November 2020

What this trial tests

NA trial testing L-PRF + DPSC in Stem Cell in 13 participants. Completed in 11 August 2020.

Timeline

20 January 2018

Primary endpoint
10 April 2020

11 August 2020

Quick facts

Lead sponsor	Baskent University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	prevention
Enrollment	13
Start date	20 January 2018
Primary completion	10 April 2020
Estimated completion	11 August 2020
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

L-PRF + DPSC
L-PRF

Conditions studied

Stem Cell — all drugs for Stem Cell →
Third Molar — all drugs for Third Molar →
Periodontal Pocket — all drugs for Periodontal Pocket →

Sponsor

Baskent University

Who can join

Adults 18 to 30, any sex, with Stem Cell or Third Molar. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to compare the clinical and radiographic effectiveness of Leukocyte-Platelet Rich Fibrin (L-PRF) and L-PRF combined with dental pulp stem cell (DPSC) application to the extraction socket of mandibular third molars.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Clinical trials using dental stem cells: 2022 update.
Song WP, Jin LY, Zhu MD, Wang H, et al · · 2023 · cited 25× · PMID 37007456 · DOI 10.4252/wjsc.v15.i3.31
The effect of dental pulp stem cells and L-PRF when placed into the extraction sockets of impacted mandibular third molars on the periodontal status of adjacent second molars: a split-mouth, randomized, controlled clinical trial.
Cubuk S, Oduncuoglu BF, Alaaddinoglu EE. · · 2023 · cited 17× · PMID 35141806 · DOI 10.1007/s10006-022-01045-2
Maxillofacial-Derived Mesenchymal Stem Cells: Characteristics and Progress in Tissue Regeneration.
Yan X, Yan F, Mohammed HAG, Liu O. · · 2021 · cited 11× · PMID 34426741 · DOI 10.1155/2021/5516521
Research progress on optimization of <i>in vitro</i> isolation, cultivation and preservation methods of dental pulp stem cells for clinical application.
Wang X, Li F, Wu S, Xing W, et al · · 2024 · cited 6× · PMID 38633667 · DOI 10.3389/fbioe.2024.1305614
Plumping up a Cushion of Human Biowaste in Regenerative Medicine: Novel Insights into a State-of-the-Art Reserve Arsenal.
Najafi-Ghalehlou N, Feizkhah A, Mobayen M, Pourmohammadi-Bejarpasi Z, et al · · 2022 · cited 5× · PMID 35505177 · DOI 10.1007/s12015-022-10383-3
Neural crest-derived mesenchymal stem cells: Fates and perspectives.
He YL, Chen SJ, Xia DS, Song WP. · · 2025 · PMID 41025106 · DOI 10.4252/wjsc.v17.i9.107689
The Therapeutic Scope of Orofacial Mesenchymal Stem Cells.
Vaddaram BC, Shakya AK, Zadeh BR, Lopez DM, et al · · 2025 · PMID 41007215 · DOI 10.3390/bioengineering12090970

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04641533 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Baskent University
Last refreshed: 24 November 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04641533.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing