Last reviewed · How we verify
NCT04636307: CHART
Characterization of Retinal Disease Progression in Eyes With Non Proliferative Diabetic Retinopathy in Diabetes Type 2 Using Non-invasive Procedures (CHART)
trial testing Biomarkers in NPDR - Non Proliferative Diabetic Retinopathy in 202 participants. Completed in 22 May 2025.
21 March 2023
Quick facts
| Lead sponsor | Association for Innovation and Biomedical Research on Light and Image |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 202 |
| Start date | 22 September 2021 |
| Primary completion | 21 March 2023 |
| Estimated completion | 22 May 2025 |
| Sites | 5 locations across Portugal, France, Italy |
Drugs / interventions tested
- Biomarkers — full drug profile →
Conditions studied
- NPDR - Non Proliferative Diabetic Retinopathy — all drugs for NPDR - Non Proliferative Diabetic Retinopathy →
- Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →
- Retinal Disease — all drugs for Retinal Disease →
Sponsor
Association for Innovation and Biomedical Research on Light and Image
Who can join
Adults 35 to 90, any sex, with NPDR - Non Proliferative Diabetic Retinopathy or Diabetes Mellitus, Type 2. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To identify biomarkers, obtained using non-invasive procedures, that can predict disease progression and progression to sight-threatening stages of the disease and to characterize the retinal changes that occur in Non Proliferative Diabetic Retinopathy (NPDR).
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Human retinal secretome: A cross-link between mesenchymal and retinal cells.
Donato L, Scimone C, Alibrandi S, Scalinci SZ, et al · · 2023 · cited 6× · PMID 37545752 · DOI 10.4252/wjsc.v15.i7.665 -
One-Year Progression of Capillary Nonperfusion in Nonproliferative Diabetic Retinopathy Using Noninvasive Imaging: The CHART Study.
Marques IP, Reste-Ferreira D, Santos T, Mendes L, et al · · 2026 · PMID 41569021 · DOI 10.1167/tvst.15.1.26
Verify or expand the search:
- PubMed search for NCT04636307
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04636307 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Association for Innovation and Biomedical Research on Light and Image
- Last refreshed: 5 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04636307.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing