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NCT04636138
Pharmacogenomic Modulators of Impaired Exercise Adaptation in Statin Users
NA trial testing Exercise in HMG-CoA Reductase Inhibitor Toxicity in 5 participants. Participants enrolled and being followed up; not accepting new ones.
30 July 2023
Quick facts
| Lead sponsor | University of Kansas Medical Center |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 5 |
| Start date | 3 June 2021 |
| Primary completion | 30 July 2023 |
| Estimated completion | 30 July 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Exercise
Conditions studied
- HMG-CoA Reductase Inhibitor Toxicity — all drugs for HMG-CoA Reductase Inhibitor Toxicity →
Sponsor
University of Kansas Medical Center
Who can join
Adults 35 to 65, any sex, with HMG-CoA Reductase Inhibitor Toxicity. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have beneficial effects (prevent stroke, heart attack) but also some bad ones (block some good effects of exercise). Individuals have genetic variations in proteins that metabolize/transport statins. The investigators hypothesize that these variations modulate the relationship between statin use and lack of benefit from exercise. The investigators will test this by having statin-users do supervised exercise for 6 weeks, measuring the cardiorespiratory fitness before/after and correlating this to genetic variations present in the participant.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04636138
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Related trials
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Trials testing the same drug.
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Other recruiting trials for HMG-CoA Reductase Inhibitor Toxicity
Currently open trials in the same condition.
- NCT04499859 — Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI · Phase 4 · recruiting
Other University of Kansas Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04636138 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Kansas Medical Center
- Last refreshed: 26 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04636138.
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