Who is sponsoring NCT04634422?

NCT04634422 is sponsored by Wladimir Szpirt.

What drugs are being tested in NCT04634422?

Interventions in NCT04634422: Plasma exchange and convalescent plasma.

What condition does NCT04634422 study?

NCT04634422 studies Respiratory Failure, Renal Failure, Acute.

Is NCT04634422 still recruiting?

NCT04634422 is currently status unknown. Last updated 21 December 2020.

Last reviewed 2020-12-21 · How we verify

NCT04634422: COVID-PLEX

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Plasma Exchange (PLEX) and Convalescent Plasma (CCP) in COVID-19 Patients With Multiorgan Failure

Status unknown NA Last updated 21 December 2020

What this trial tests

NA trial testing Plasma exchange and convalescent plasma in Respiratory Failure in 220 participants. Status unknown.

Timeline

16 November 2020

Primary endpoint
30 June 2021

30 June 2022

Quick facts

Lead sponsor	Wladimir Szpirt
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	220
Start date	16 November 2020
Primary completion	30 June 2021
Estimated completion	30 June 2022
Sites	1 location across Denmark

Drugs / interventions tested

Plasma exchange and convalescent plasma

Conditions studied

Respiratory Failure — all drugs for Respiratory Failure →
Renal Failure, Acute — all drugs for Renal Failure, Acute →

Sponsor

Wladimir Szpirt

Who can join

18 and older, any sex, with Respiratory Failure or Renal Failure, Acute. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This Randomized Control Trial (RCT) proposes combination of extracorporeal cytokine removal by plasma exchange (PLEX) and additional infusion of convalescent plasma (CCP) collected from COVID-19 recovered individuals at the end of the PLEX procedure. The combination of cytokine removal by PLEX and CCP infusion is in onvestigators opinion more rational compared to CCP infusion alone and as such probably more effective in reducing the duration of mechanical ventilation, length of stay in the intensive care unit, and potentially also mortality.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Convalescent plasma or hyperimmune immunoglobulin for people with COVID-19: a living systematic review.
Piechotta V, Iannizzi C, Chai KL, Valk SJ, et al · · 2021 · cited 106× · PMID 34013969 · DOI 10.1002/14651858.cd013600.pub4
Convalescent plasma for people with COVID-19: a living systematic review.
Iannizzi C, Chai KL, Piechotta V, Valk SJ, et al · · 2023 · cited 24× · PMID 36734509 · DOI 10.1002/14651858.cd013600.pub5
Convalescent plasma for people with COVID-19: a living systematic review.
Iannizzi C, Chai KL, Piechotta V, Valk SJ, et al · · 2023 · cited 21× · PMID 37162745 · DOI 10.1002/14651858.cd013600.pub6
Use of therapeutic plasma exchange in COVID-19: A systematic review of current evidence.
Carlson N, Szpirt WM. · · 2022 · cited 4× · PMID 36468346 · DOI 10.1111/1744-9987.13779
Reporting of Hospital-Free Days As an Outcome Measure in Critical Care Trials: A Systematic Review.
Shackleton R, Shackleton R, Vollam S, Gerry S, et al · · 2025 · cited 1× · PMID 40938146 · DOI 10.1097/ccm.0000000000006858

Verify or expand the search:

Other recruiting trials for Respiratory Failure

Currently open trials in the same condition.

NCT07522450 — Benefit of Sleep Quality Monitoring by EEG in ICU · recruiting
NCT07359261 — Transpulmonary Assessment for Individualized Lung Optimization in Obese Patients · Phase 2 · recruiting
NCT07536750 — Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive V · recruiting
NCT07114289 — Spontaneous Breathing Trials Using Pressure Support or T-Piece in Overweight and Obese Patients · NA · recruiting
NCT06591533 — The Effect of Music Therapy on Vital Signs and Heart Rate Variability of Pediatric Patients During the Extubation Proces · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04634422 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Wladimir Szpirt
Last refreshed: 21 December 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04634422.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing