NCT04634383: ICVP

A Phase I Feasibility Study of an Intracortical Visual Prosthesis (ICVP) for People With Blindness

Status unknown NA Last updated 11 January 2022

What this trial tests

NA trial testing WFMA - wireless floating microelectrode array in Ocular Injury in 5 participants. Status unknown.

Timeline

20 August 2020

Primary endpoint
31 August 2023

31 August 2023

Quick facts

Lead sponsor	Illinois Institute of Technology
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	device feasibility
Enrollment	5
Start date	20 August 2020
Primary completion	31 August 2023
Estimated completion	31 August 2023
Sites	1 location across United States

Drugs / interventions tested

• WFMA - wireless floating microelectrode array

Conditions studied

• Ocular Injury — all drugs for Ocular Injury →
• Optic Nerve Diseases — all drugs for Optic Nerve Diseases →
• Photoreceptor Degeneration — all drugs for Photoreceptor Degeneration →
• Blindness,Acquired — all drugs for Blindness,Acquired →

Sponsor

Illinois Institute of Technology — full company profile →

Who can join

Adults 19 to 70, any sex, with Ocular Injury or Optic Nerve Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine the feasibility of producing artificial vision in persons with blindness. Study participants will have wireless electrical stimulators implanted into the cortical vision processing areas of their brains. The ability of the participants to perceive artificial vision in response to electrical stimulation will be assessed.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Use of Invasive Brain-Computer Interfaces in Pediatric Neurosurgery: Technical and Ethical Considerations.
   Bergeron D, Iorio-Morin C, Bonizzato M, Lajoie G, et al · · 2023 · cited 26× · PMID 37116888 · DOI 10.1177/08830738231167736
2. An update on visual prosthesis.
   Ramirez KA, Drew-Bear LE, Vega-Garces M, Betancourt-Belandria H, et al · · 2023 · cited 23× · PMID 37996905 · DOI 10.1186/s40942-023-00498-1
3. A narrative review of cortical visual prosthesis systems: the latest progress and significance of nanotechnology for the future.
   Liu X, Chen P, Ding X, Liu A, et al · · 2022 · cited 19× · PMID 35845476 · DOI 10.21037/atm-22-2858
4. New frontiers of retinal therapeutic intervention: a critical analysis of novel approaches.
   Nanegrungsunk O, Au A, Sarraf D, Sadda SR. · · 2022 · cited 14× · PMID 35467460 · DOI 10.1080/07853890.2022.2066169
5. Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases.
   Sanie-Jahromi F, Azizi A, Shariat S, Johari M. · · 2021 · cited 9× · PMID 34840978 · DOI 10.1155/2021/6548554
6. Chronic stability of activated iridium oxide film voltage transients from wireless floating microelectrode arrays.
   Frederick RA, Shih E, Towle VL, Joshi-Imre A, et al · · 2022 · cited 8× · PMID 36003961 · DOI 10.3389/fnins.2022.876032
7. Tackling visual impairment: emerging avenues in ophthalmology.
   Lin F, Su Y, Zhao C, Akter F, et al · · 2025 · cited 4× · PMID 40357281 · DOI 10.3389/fmed.2025.1567159
8. Clinical Progress and Optimization of Information Processing in Artificial Visual Prostheses.
   Wang J, Wang J, Zhao R, Li P, et al · · 2022 · cited 4× · PMID 36081002 · DOI 10.3390/s22176544