Who is sponsoring NCT04633681?

NCT04633681 is sponsored by University of Leeds.

What drugs are being tested in NCT04633681?

Interventions in NCT04633681: Sweetener and sweetness enhancer consumption.

What condition does NCT04633681 study?

NCT04633681 studies Eating Behavior.

Is NCT04633681 still recruiting?

NCT04633681 is currently completed. Last updated 12 August 2024.

Last reviewed 2024-08-12 · How we verify

NCT04633681: SWEET-WP2-P2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Impact of Sweeteners on Behaviour, Physiology & Health

Completed NA Last updated 12 August 2024

What this trial tests

NA trial testing Sweetener and sweetness enhancer consumption in Eating Behavior in 175 participants. Completed in 20 November 2023.

Timeline

1 April 2021

Primary endpoint
29 September 2023

20 November 2023

Quick facts

Lead sponsor	University of Leeds
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	basic science
Enrollment	175
Start date	1 April 2021
Primary completion	29 September 2023
Estimated completion	20 November 2023
Sites	5 locations across Denmark, United Kingdom, France, Spain

Drugs / interventions tested

Sweetener and sweetness enhancer consumption

Conditions studied

Eating Behavior — all drugs for Eating Behavior →

Sponsor

University of Leeds

Who can join

Adults 18 to 60, any sex, with Eating Behavior. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aims to evaluate the acute (1-day) and repeated (2-week) effects of combinations of Sweeteners \& Sweetness Enhancer blends on metabolic, sensory, neuro-behavioural and microbiota-mediated processes involved in satiety, consumer preferences and health.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Acute and two-week effects of neotame, stevia rebaudioside M and sucrose-sweetened biscuits on postprandial appetite and endocrine response in adults with overweight/obesity-a randomised crossover trial from the SWEET consortium.
Gibbons C, Beaulieu K, Almiron-Roig E, Navas-Carretero S, et al · · 2024 · cited 8× · PMID 38553262 · DOI 10.1016/j.ebiom.2024.105005
<i>TAS1R2</i>/<i>TAS1R3</i> Single-Nucleotide Polymorphisms Affect Sweet Taste Receptor Activation by Sweeteners: The SWEET Project.
Belloir C, Jeannin M, Karolkowski A, Briand L. · · 2025 · cited 5× · PMID 40289963 · DOI 10.3390/nu17060949
Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obesity - the SWEET Project.
Gibbons C, O'Hara B, O'Connor D, Hardman C, et al · · 2022 · cited 4× · PMID 36564114 · DOI 10.1136/bmjopen-2022-063903

Verify or expand the search:

Other recruiting trials for Eating Behavior

Currently open trials in the same condition.

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NCT06175988 — Visceral Adiposity, Vagal Tone and Food Preferences: a Pilot Study · recruiting
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NCT06108128 — Food for Thought: Executive Functioning Around Eating Among Children · NA · recruiting

Other University of Leeds trials

Trials by the same sponsor.

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NCT07247812 — tSCS in Children and Young People With HCP · NA · not yet recruiting
NCT07181915 — Changing Outcomes Through Achievement Emails in COPD Using Routine Healthcare Audits · NA · active not recruiting
NCT06240403 — Digoxin and Senolysis in Heart Failure and Diabetes Mellitus · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04633681 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Leeds
Last refreshed: 12 August 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04633681.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing